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A meta-analysis of genome-wide association studies of growth differentiation Factor-15 concentration in blood
... silico analysis suggests it has a likely regulatory role and is an eQTL for ...in blood for B3GALT6 and TNFRSF18, which have been implicated in MIC-1/GDF-15 protein binding and immune function ...in ... See full document
5
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
... , Seattle, WA, USA) Garnet Anderson, Ross Prentice, Andrea LaCroix and Charles Kooperberg; Investigators and Academic Centers (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) JoAnn E. Manson; ... See full document
12
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip
... To further investigate our fi ndings for the top GWS hit at 20q13 we explored mRNA expression pro fi le of the NCOA3 gene in articular cartilage, a highly relevant tissue for OA. Expression of the gene was examined by ... See full document
103
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
... , Seattle, WA, USA) Garnet Anderson, Ross Prentice, Andrea LaCroix and Charles Kooperberg; Investigators and Academic Centers (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) JoAnn E. Manson; ... See full document
12
Qiu-Yue Zhang 1,* , Hui-Fu Wang 1,* , Zhan-Jie Zheng 2, Ling-Li Kong2 , Meng-Shan Tan 1, Chen-Chen Tan1 , Wei Zhang 3, Zi-Xuan Wang1 , Lin Tan 4, Jin-Tai Yu1 and Lan Tan 1
... recent meta-analysis of genome-wide association studies (GWAS) in population of Caucasian identified a single nucleotide polymorphism (SNP) rs17125944 in the FERMT2 gene as a new ... See full document
32
Genome wide association study meta analysis identifies five new loci for systemic lupus erythematosus
... present meta-analysis, we found an association between an intronic SNP in the gene encoding for the growth factor receptor-bound protein GRB2 and SLE (rs36023980, p = ...). ... See full document
11
Genome-Wide Association Studies in Glioma.
... Recent reports assessing associations with glioma at telomere risk loci (53) suggest that increased telomere length is a risk factor for glioma (132). However, these telomere length estimates were based on data ... See full document
8
Genome wide association studies: a primer
... the association signal (fine- ...these studies, but it has been estimated that by direct genotyping and imputation a large percentage (>85 %) of common SNP variation is already being assayed by GWAS, ... See full document
103
Genome-wide association studies with metabolomics
... In the past, candidate gene and pedigree analyses were very successful in the study of diseases of monogenetic origin: heritable dysregulation of certain metabolomic traits (inborn errors of metabolism) were among the ... See full document
47
GENOME-WIDE ASSOCIATION STUDIES IN PHARMACOGENOMICS
... human genome is composed of about twenty thousand genes, and it is variable among individuals ...the genome found in more than 1% of the population ...for 15– 30% of inter-individual differences in ... See full document
7
On Considering Epistasis in genome Wide Association Studies.
... locus association tests among genetic variants previously associated with tuberculosis susceptibility, IL-1β +3953 was associated with extrapulmonary disease, as well as all forms of tuberculosis, compared to ... See full document
19
Genome-wide association meta-analysis of functional outcome after ischemic stroke
... suggestive association with ordinal mRS and was also associated with dichotomous mRS at a low p ...neurite growth, and ...in blood vessels and astro- cytes in the ischemic core after stroke, and ... See full document
7
The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction
... In the present study, we aimed to investigate whether genetic variations in genes that encode proteins expressed in smooth muscle cells (PECAM1, HIF1A) and endothelial cells (KIAA1462) influence MI risk in Han Chinese. ... See full document
5
Genomic Approaches to Understanding Variable Expressivity in Alagille Syndrome and Genetic Susceptibility to Biliary Atresia
... our studies investigating the possible genetic components of liver disease severity, starting with studies to analyze JAG1 (both the mutated and non-mutated alleles) to hypothesis-neutral ... See full document
6
Two patients walk into a clinic a genomics perspective on the future of schizophrenia
... provided significant evidence for ten susceptibility loci [8-13] (Table 1). In keeping with the epidemiological data and polygene score analysis, many of these loci appear to confer liability to both schizophrenia ... See full document
7
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
... these studies and the current study (overlaps are: educational attainment, N ~ 30 000; childhood general cognitive function, N ~ ...be genome-wide signi fi cant for both general cognitive function and ... See full document
7
Structural Brain MRI Trait Polygenic Score Prediction of Cognitive Abilities
... the meta-analysis of all cohorts further supports this finding representing type 1 ...cognitive factor (results not shown), which are strongly correlated with MHT scores again points to type 1 ... See full document
137
Gene based bin analysis of genome wide association studies
... expected to be discarded. 9 422 were for collection A. It can be explained (i) by artifacts of DM calling algorithm which has a higher error rate on heterozygotic genotypes (ii) by deviations from the assumptions ... See full document
97
Genome-wide association analysis of body conformation traits in Mexican Holstein cattle using a mix of sampled and imputed SNP genotypes.
... a genome-wide association analysis for a set of sampled and imputed SNPs with 16 conformation traits in a population of Mexican Holstein cows, revealed eight significant SNPs: one associated ... See full document
18
Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies
... observe association in spite of the large number of samples assembled (the largest ever studied for most candidate genes) and the more tolerant threshold for significance allowed by the focused ...our ... See full document
107
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