[PDF] Top 20 Synthesis and cytotoxic activity of geranylmethoxyhydroquinone derivatives
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Synthesis and cytotoxic activity of geranylmethoxyhydroquinone derivatives
... concentration of a drug that is required for 50% inhibition in vitro after 72 h of treatment with the test ...2-4 and 6 did not affect the viability of the cells lines studied, however the ... See full document
5
Design and Synthesis of Pironetin Analogue/Combretastatin A 4 Hybrids and Evaluation of Their Cytotoxic Activity
... structures and the observed cytotoxicity deserve comment. In the case of two subsets of hybrid molecules [27] where there are differences between in the carbon chain length ...1-4 and 5-8), ... See full document
18
Synthesis and in vitro antimicrobial activity of novel hydrazide-hydrazone derivatives of dodecanoic acid
... Six new dodecanoic acid hydrazide-hydrazones (compounds 4a–f ), unsubstituted or carrying hy- droxy, methoxy, nitro and chloro groups on the benzene ring, were synthesized and tested, [r] ... See full document
1
Design and Synthesis of Pironetin Analogue/Colchicine Hybrids and Study of Their Cytotoxic Activity and Mechanisms of Interaction with Tubulin
... Total synthesis of (−)-PA-48153C, a novel immunosuppressive 2- pyranone ...Total synthesis of a potent immunosuppressant ...Total synthesis of (−)-PA-48153C (pironetin) utilising ... See full document
14
Synthesis and antiproliferative activity of new cyclodiprenyl phenols against select cancer cell lines
... avinosol and avarol offer promising opportunities for the development of new antitumor agents ...potential of meroterpenes is of great interest; however, low yields of these compounds ... See full document
13
Hemi Synthesis and Anti Oomycete Activity of Analogues of Isocordoin
... subclass of naturally occurring chalcones [1]. The biosynthesis of C-prenyl chalcones involves the coupling of products from the shikimic and mevalonic acid ...80% of these molecules ... See full document
9
Synthesis, Cytotoxic and Antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one Derivatives
... As complementary biological test, all 4-thiazolidinones were evaluated for antimicrobial activity against various bacterial and fungal species..[r] ... See full document
1
Antiplasmodial and Cytotoxic Activity of Piper Piedecuestanum Trel and Yunck
... fractionation and isolation of the major substances. The extract of dichloromethane (PPD) of the species of ...Trel. and Yunck. (4.89 g) was active and was fractionated by ... See full document
9
3. SAPOGENINS FROM THE HUSK OF CHENOPODIUM QUINOA, THE OBTAINING OF THEIR DERIVATIVES, AND THE EVALUATION OF THEIR CYTOTOXIC ACTIVITY.
... Cytotoxic evaluation The cytotoxicity of the four isolated sapogenins was evaluated in one normal-like human breast epithelial cell line MCF-10A and in one breast cancer cell line JIMT-1[r] ... See full document
10
Synthesis and evaluation of the antifungal activity of 2-(substituted-amino)-4,5-dialkyl-thiophene-3- carbonitrile derivatives
... All compounds presented fungicidal activity at different doses, but a few compounds showed moderate or poor antifungal activity when compared with the standard drugs. The Cryp- tococcus[r] ... See full document
1
Unveiling interactions between DNA and cytotoxic 2 arylpiperidinyl 1,4 naphthoquinone derivatives: A combined electrochemical and computational study
... (Martı´nez and Benito 2005; Salas et al., 2011; Kumagai et al., 2012; Tandon and Kumar 2013; Klotz et ...significant and largely distributed family of quinones are those based on the ... See full document
12
Synthesis, anti-inflammatory and analgesic activity of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1,2,4-triazole derivatives
... The title compounds were investigated for anti-inflammatory and analgesic activities using carrageenan induced rat paw edema and acetic induced writhing test, respectively. All the test [r] ... See full document
1
Synthesis and Anti-HIV Activity Evaluation of 2-(5-(Naphthalen-1-yl)-1,2,3-thiadiazol-4-ylthio)-N-acetamides Derivatives
... development of novel HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating novel structures of increased ... See full document
1
Determination of the cytotoxic capacity of organotin compounds derivatives from salicylidene benzoylhidrazone
... carboplatin and nedaplatin, which are metalocomplexes platinum (II) x ...high activity, the application of cisplatin and similar compounds has significant disadvantages which include: poor ... See full document
111
Synthesis and cytotoxic activity of tri acyl ester derivatives of uridine in breast cancer cells
... uridine and derivatives was observed with ...fect and a higher activity over cell viability on MCF-7 hu- man cancer breast cell line than for the CHO-K1 cell ...Some of the uridine ... See full document
9
SYNTHESIS OF GERANYLHYDROQUINONE DERIVATIVES WITH POTENCIAL CYTOTOXIC ACTIVITY
... µL) and incubating for 60 min at 4 ...water and dried; SRB solution ...well and incubated for 30 min at room ...air-dried and bound stain was solubilized with Tris base (100 µL, 10 ... See full document
10
Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity
... These complexes were characterized and the results shown that the ligand is coordinated to platinum or palladium by the basic nitrogen of NH 2 group and have the general structure cis- [r] ... See full document
1
Synthesis and cytotoxic activity of per acetylated and halogenated derivatives of nucleosides in breast cancer cells
... overlapping of H-5’ and H-6’ protons of ribose ring) with a high deshielding signal ...(H-4’) and other highly deshield- ed signal ...(H-2’) of the ribose ...H-5’ and H-6’protons ... See full document
10
Synthesis and conformational analysis of leptocarpin derivatives Influence of modification of the oxirane ringon leptocarpin's cytotoxic activity
... point of view, leptocarpin under acid conditions can produce two types of cyclation ...attack of the double bond ∆ 4,5 on C10 (6-Exo-Tet) producing the opening of the oxirane ring (Figure ... See full document
15
Design and synthesis of pironetin analogue/combretastatin A 4 hybrids containing a 1,2,3 triazole ring and evaluation of their cytotoxic activity
... -tubulin and those that bind to b ...numerous and contains products which cause either disruption or stabilization of ...[6] and the combretastatins [7] ...disruption of microtubules. ... See full document
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