[PDF] Top 20 Las TIC en el proceso de enseñanza aprendizaje en el área de Lengua y Literatura.
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Tiotropium/olodaterol versus tiotropium in Japanese patients with COPD: results from the DYNAGITO study
... the Japanese subgroup did not differ between the TIO and TIO + OLO arms ...overall study popu- lation (TIO arm ...the Japanese subgroup were consistent for most AEs, except for the AEs of ... See full document
22
The efficacy and safety of combined tiotropium and olodaterol via the Respimat<sup>®</sup> inhaler in patients with COPD: results from the Japanese sub-population of the Tonado<sup>®</sup> studies
... the Japanese sub-population compared to the overall population but a lower incidence of COPD (including COPD ...in patients with COPD, the most frequent events occurred in the System ... See full document
11
UK-specific cost-effectiveness of tiotropium + olodaterol fixed-dose combination versus other LAMA + LABA combinations in patients with COPD
... with results of an analysis of LAMA + LABA combination treatments in comparison with tiotropium + olodaterol FDC from a UK payer ...in COPD, a chronic condition with considerable ... See full document
9
Cost-effectiveness of combination therapy umeclidinium/vilanterol versus tiotropium in symptomatic COPD Spanish patients
... the results more robust, being the first published Spanish analysis that incorporates utility values of Spanish COPD ...directly from generic patient questionnaires is recommended whenever ...The ... See full document
20
Lung function and long-term safety of tiotropium/olodaterol in East Asian patients with chronic obstructive pulmonary disease
... studies, patients received tiotropium/olodaterol, tiotro- pium, or ...curve from 0 to 3 hours (AUC 0–3 ) response and trough FEV 1 response at 24 weeks for the approved doses, ... See full document
8
<p>Long-term cost-effectiveness of the fixed-dose combination of tiotropium plus olodaterol based on the DYNAGITO trial results</p>
... large tiotropium trials used to build the model did not include sufficient data on utility values, equation-predicted utility values based on different patient and disease characteristics could not be ...includes ... See full document
8
Impact of tiotropium + olodaterol on physical functioning in COPD: results of an open-label observational study
... (37 patients, ...(46 patients, ...(2.4%) patients had at least one treat- ment-emergent AE that was deemed to be causally related to tiotropium and olodaterol, ...35 patients who ... See full document
9
<p>No Influence on Cardiac Arrhythmia or Heart Rate from Long-Term Treatment with Tiotropium/Olodaterol versus Monocomponents by Holter ECG Analysis in Patients with Moderate-to-Very-Severe COPD</p>
... All patients provided written informed ...opinion from a constituted local Institutional Review Board or an Independent Ethics Committee at each center prior to the start of the ...granted from ... See full document
10
Efficacy of tiotropium–olodaterol fixed-dose combination in COPD
... of COPD patients at high risk of exacerbations (based upon prior exacerbation history and severity of airflow obstruc- tion) will elucidate the question of whether dual broncho- dilatation is superior to ... See full document
24
Efficacy and safety of tiotropium Respimat<sup>®</sup> SMI in COPD in two 1-year randomized studies
... of tiotropium were also seen in the fourth co-primary efficacy endpoint of COPD exacerbations (Table ...mean COPD exacerbation rate (per patient- year) was statistically significantly reduced on ... See full document
12
<p>Assessment of physical functioning and handling of tiotropium/olodaterol Respimat® in patients with COPD in a real-world clinical setting</p>
... of patients were either “ very satis fi ed ” or “ satis fi ed ” with receiving tiotropium/ olodaterol ...identical results were observed with regard to patient satisfaction with the hand- ling ... See full document
23
Ten years of tiotropium: clinical impact and patient perspectives
... In COPD, the mucous glands during an exacerbation will produce copious amount of secretion (hypersecretion), which may contribute to airflow ...of tiotropium during this situation, which might lead to ... See full document
18
<p>Effect of tiotropium/olodaterol on sedentary and active time in patients with COPD: post hoc analysis of the VESUTO<sup>®</sup> study</p>
... with COPD are markedly inactive because of air fl ow ...with COPD engage in activity, it is characterized by shortness of breath because of lung hyperin fl ...in patients with COPD, the risk of ... See full document
17
Does tiotropium lower exacerbation and hospitalization frequency in COPD patients: results of a meta-analysis
... 13. Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, Decramer M, Investigators US, Schiavi E, Figueroa Casas JC, Rhodius E, Gene R, Benito Saenz C, Giugno E, Di Bartolo C, De Salvo MC, Abbate E, Lopez AM, ... See full document
10
<p>Absence of Adverse Effects of Tiotropium/Olodaterol Compared with the Monocomponents on Long-Term Heart Rate and Blood Pressure in Patients with Moderate-to-Very-Severe COPD</p>
... fees from Boehringer Ingelheim and GlaxoSmithKline, and payments for presenting from Boehringer Ingelheim, AstraZeneca, Berlin Chemie, Chiesi and Novartis, outside the submitted ...support from ... See full document
10
Cost-effectiveness and budget impact of the fixed-dose dual bronchodilator combination tiotropium–olodaterol for patients with COPD in the Netherlands
... As COPD is a chronic condition and according to the Dutch pharmacoeco- nomics guidelines, the model allowed patients to be followed over their lifetime, defined as a maximum period of 60 years, or a maximum ... See full document
10
Efficacy of tiotropium/olodaterol on lung volume, exercise capacity, and physical activity
... Tokyo, Japan; Hiroyuki Nakamura, Sakaide City Hospital, Sakaide, Kagawa, Japan; Yusuke Shikama, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan; Shinichi Osaki, Osaki Internal and Respiratory Clinic, ... See full document
8
<p>Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD</p>
... in patients for the ef fi cacy trials NCT01313637 23 and NCT01313650 24 in COPD ...VI from more than 16,000 samples resulted in a two-compartment pharmaco- kinetic model with fi rst-order ... See full document
16
Tiotropium reduces risk of exacerbations irrespective of previous use of inhaled anticholinergics in placebo-controlled clinical trials
... In patients who discontinued anticholinergic therapy, there was a 17% risk reduction for an exacerbation when treated with tiotropium compared with ...In patients who did not discontinue ... See full document
25
Comorbidities of patients in tiotropium clinical trials: comparison with observational studies of patients with chronic obstructive pulmonary disease
... of COPD. Written informed consent was obtained from all patients and ethics committee approval was obtained for all ...the tiotropium COPD development program, inclusion and exclusion ... See full document
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