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Health status and lung function in the Swedish alpha 1-antitrypsin deficient cohort, identified by neonatal screening, at the age of 37-40 years
... The most important limitation of our study is the fact that some AAT-deficient subjects did not participate in the follow-up pulmonary function tests. The most common reason for not participating was lack ... See full document
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<p>Survival in the Swedish cohort with alpha-1-antitrypsin deficiency, up to the age of 43–45 years</p>
... This cohort is the one of the most important existing, population-based, epidemiological study on the natural his- tory of severe and moderate AAT deficiency that was started by a neonatal screening ... See full document
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Lung function and CT lung densitometry in 37- to 39-year-old individuals with alpha-1-antitrypsin deficiency
... Background: Alpha-1-antitrypsin (AAT) deficiency is a hereditary disorder that predisposes to ...A cohort of severe (PiZZ) and moderate (PiSZ) AAT-deficient newborn infants was ... See full document
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Jaundice revisited: recent advances in the diagnosis and treatment of inherited cholestatic liver diseases
... NH: Neonatal hepatitis; NICCD: Neonatal cholestasis caused by citrin deficiency; NTCP: Sodium/taurocholate co- transporting polypeptide; OATP1B1/3: Organic-anion-transporting polypeptide 1B1 and 1B3; OST α ... See full document
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Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review
... Figure 1 shows the selection criteria. Systematic reviews and primary study designs assessing treatment were eli- gible provided they included data on $10 participants with AATD. Nonsystematic reviews and ... See full document
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Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor
... conducted by the National Heart Lung and Blood institute (NHLBI) AATD Registry Group. The most frequent reported side effects include headache, dizziness, nausea, and dyspnea [5]. Although acute allergic reactions, ... See full document
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Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency
... In order to explain the combination of the two phenom- ena observed in Mmalton, i.e. calcifications and lack of reactivity to the monoclonal ATZ11 antibody, we have in- ferred that Mmalton, among these three variants, is ... See full document
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Long-term evolution of lung function in individuals with alpha-1 antitrypsin deficiency from the Spanish registry (REDAAT)
... of alpha-1 antitrypsin deficiency (AATD) is very ...long-term lung function in individuals with AATD-associated emphysema after at least 8 years of ...in 1 second (FEV ... See full document
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Lung transplantation and survival outcomes in patients with oxygen-dependent COPD with regard to their alpha-1 antitrypsin deficiency status
... K00–K93), lung cancer (162; C34), and other cancers (140–239 × ; ...Vital status was obtained from the National Causes of Death ...using Swedish system of personal identity ... See full document
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Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency
... reported from the German registry compared to the US registry suggests there were more cases of anaphylactic reactions in the European study (four patients versus none, respectively), while side effects requiring medical ... See full document
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Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes
... Abstract: Alpha-1 antitrypsin (AAT) deficiency remains an underrecognized genetic disease with predominantly pulmonary and hepatic ...In deficient states, unrestrained NE activity promotes ... See full document
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The prevalence of alpha 1 antitrypsin deficiency in Ireland
... The relatively high frequency of the S mutation could suggest that the tribes who first settled on Irish shores may have migrated from the Iberian Peninsula. The S mutation is older than the Z and is postulated to have ... See full document
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Intimate Partner Violence, Welfare Receipt, and Health Status of Low‐Income African American Women: A Lifecourse Analysis
... mental health may impede women’s abilities to apply for exemptions, follow through with referrals, or fulfill other program requirements (such as filling out forms and attending support group meetings); women may ... See full document
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Higher population‐based incidence rates of triple‐negative breast cancer among young African‐American women
... tribution for breast cancer in this population subset. Early detection of breast cancer is the most powerful determi- nant of outcome, and this will be particularly relevant for tumors that express phenotypes that cannot ... See full document
17
Geriatric screening in first opinion practice: results from 45 dogs
... of age-related ...frequently identified at the time of ...metastatic lung disease. Screening resulted in 29 further diagnostic procedures, including 10 dental procedures, seven medical ... See full document
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Randomized, Controlled Trial of Dexamethasone in Neonatal Chronic Lung Disease: 13- to 17-Year Follow-up Study: II. Respiratory Status, Growth, and Blood Pressure
... an increase of ⬍ 10% over the baseline value), and frequency of respiratory symptoms, inhaler use, and hospital admissions. Other secondary outcome measures included weight, height, BMI, and head circumference z scores ... See full document
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Alpha-1-antitrypsin augmentation therapy in deficient individuals enrolled in the Alpha-1 Foundation DNA and Tissue Bank
... 5 years was performed with the use of logistic regression with age, gender, baseline FEV 1 , presence of COPD and smoking status as ... See full document
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Heterozygous Alpha-1-Antitrypsin Deficiency and Respiratory Function in Children
... However, when subjects were matched to avoid other genetic or environmental biases, statistically significant differences in pulmonary function were noted in Pi type MZ children compared[r] ... See full document
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Expression of the alpha 1 antitrypsin gene in mononuclear phagocytes of normal and alpha 1 antitrypsin deficient individuals
... in alpha 1AT in a fashion similar to ...of alpha 1AT gene expression, but these cells may contribute to the levels of alpha 1AT present in the lower respiratory tract in the normal and ZZ ... See full document
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A comparative ultrastructural and molecular biological study on Chlamydia psittaci infection in alpha 1 antitrypsin deficiency and non alpha 1 antitrypsin deficiency emphysema versus lung tissue of patients with hamartochondroma
... Our previous investigations by means of immunofluores- cence using a genus-specific antiserum against chlamydial LPS and scanning as well as transmission electron micro- scopy showed infection of the alveolar parenchyma ... See full document
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