ANEXO R1.2. CLASIFICACIÓN FUNCIONAL DE GENES INDUCIDOS O REPRIMIDOS EN SP1-3

(1)

Clasificación funcional de genes inducidos (panel A, B, C) o reprimidos (panel D, E, F) en SP1, SP2 y SP3 en comparación con SP0, respectivamente. El conjunto de genes de cada comparación fue agrupado en categorías funcionales de acuerdo a la nomenclatura MIPS (http://mips.helmholtz-muenchen.de). Cluster: número de genes de cada comparación clasificados dentro de una categoría específica.

Genoma: número de genes total de un categoría específica. El p-valor representa la probabilidad de que la intersección de una lista de genes de interés con una categoría funcional determinada ocurra por azar; éste se ha obtenido mediante análisis hipergeométrico.

A

CATEGORÍA FUNCIONAL MIPS p-valor GENES CLUSTER GENOMA

02 ENERGÍA 7.63E-33 YAL054C YAL061W YBL045C YBL080C YBR001C YBR026C YBR039W YBR105C YBR117C YBR299W YCL040W YCR105W YCR107W YDL004W YDL067C YDL085W YDL130W-A YDL174C

YDL181W YDL215C YDL243C YDR074W YDR079W YDR148C YDR178W YDR231C YDR255C YDR377W YDR529C YEL011W YEL012W YEL020C YEL024W YER054C YER141W YFL030W YFR003C YFR033C YFR053C YGL062W YGL134W YGL187C YGL191W YGL205W YGL226W YGL227W YGR008C YGR032W

YGR043C YGR174C YGR183C YGR244C YGR248W YGR256W YGR287C YHR001W-A YHR051W YIL045W YIL097W YIL107C YIL111W YIL155C YIL160C YJL003W YJL089W YJL137C YJL155C

YJL166W YJR019C YJR048W YJR155W YKL016C YKL055C YKL085W YKL093W YKL141W YKL148C YKL150W YKR016W

YKR046C YKR058W YKR097W YLL041C YLR038C YLR134W YLR258W YLR295C YLR345W YML054C YML081C-A YML087C YML100W YML120C YMR030W YMR081C YMR105C YMR118C YMR145C YMR244W YMR256C YMR280C YMR303C YMR323W

YNL009W YNL037C YNL052W YNL134C YNL202W YNL237W YNL241C YNL331C YNR001C YOL077W-A YOL151W YOR065W

YOR136W YOR178C YOR347C YOR374W YOR388C YPL061W

134 367

(2)

YPL078C YPL171C YPL240C YPL262W YPL271W YPR001W YPR006C YPR020W YPR026W YPR155C YPR160W YPR184W

YPR191W

02.11 Conservación de energía de

membrana 8.07E-23

YBL045C YBR039W YDL004W YDL067C YDL085W YDL130W-A YDL181W YDR178W YDR231C YDR377W YDR529C YEL024W YFR033C YGL187C YGL191W YGR008C YGR183C YHR001W-A YHR051W YIL111W YJL166W YJR048W YKL016C YKL141W

YKL148C YKL150W YLL041C YLR038C YLR295C YML054C YML081C-A YML120C YMR145C YMR256C YNL052W YOL077W-

A YOR065W YPL078C YPL271W YPR020W YPR191W

41 61

02.13 Respiración 2.86E-19

YBL045C YBL080C YBR026C YBR039W YDL004W YDL067C YDL085W YDL130W-A YDL174C YDR079W YDR178W YDR231C

YDR377W YDR529C YEL024W YER141W YFR033C YGL187C YGL191W YGL226W YGR008C YGR174C YGR183C YHR001W-A

YHR051W YIL111W YIL155C YJL003W YJL166W YJR048W YKL016C YKL055C YKL093W YKL141W YKL148C YKL150W YKR016W YKR046C YLL041C YLR038C YLR295C YML054C YML081C-A YML087C YML120C YMR030W YMR081C YMR145C

YMR244W YMR256C YNL052W YNL237W YOL077W-A YOR065W YOR374W YPL078C YPL271W YPR020W YPR155C

YPR191W

60 138

02.13.03 Respiración aeróbica 3.35E-13

YBL045C YBL080C YBR026C YDL067C YDL085W YDL174C YDR079W YDR178W YDR231C YDR529C YEL024W YFR033C YGL187C YGL191W YGR183C YHR001W-A YHR051W YIL111W

YJL003W YJL166W YKL055C YKL093W YKL141W YKL148C YKR046C YLL041C YLR038C YML120C YMR030W YMR081C YMR145C YMR256C YNL052W YOR065W YPR155C YPR191W

36 77

20.01.15 Transporte electrónico 6.85E-10

YBR039W YCR083W YDL004W YDL067C YDL085W YDL130W-A YDL181W YDR178W YDR377W YDR513W YGL187C YGL191W

YGR008C YHR051W YIL111W YJR048W YKL016C YKL141W YKL148C YKL150W YLL041C YLR038C YLR295C YML081C-A YMR145C YMR256C YNL052W YOL077W-A YOR065W YPL078C

YPL171C YPL271W YPR020W

33 83

01.05 Metabolismo de

carbohidratos y compuestos del C 1.51E-09 YAL017W YAL054C YAL061W YBL015W YBL021C YBR001C YBR050C YBR117C YBR297W YBR299W YCL040W YCR105W YCR107W YDL124W YDL168W YDL174C YDL194W YDL243C YDL246C YDR009W YDR036C YDR043C YDR074W YDR148C

112 505

(3)

YDR178W YDR216W YDR221W YDR248C YDR277C YEL011W YEL020C YER054C YER062C YER096W YER175C YFL014W YFR053C YGL062W YGL125W YGL134W YGL156W YGR019W

YGR032W YGR043C YGR244C YGR256W YGR287C YHL032C YHR104W YIL045W YIL050W YIL099W YIL107C YIL155C

YIL162W YJL137C YJL153C YJL155C YJR155W YKL038W YKL085W YKL109W YKL141W YKL148C YKR058W YKR097W

YLL041C YLR070C YLR134W YLR251W YLR258W YLR345W YML054C YML100W YMR020W YMR105C YMR280C YMR303C YMR306W YMR311C YMR323W YNL009W YNL037C YNL134C YNL241C YNL274C YNL331C YNR001C YNR002C YNR071C YOL132W YOR040W YOR120W YOR136W YOR178C YOR347C

YOR358W YOR374W YOR388C YPL017C YPL026C YPL057C YPL061W YPL113C YPL201C YPL262W YPR001W YPR002W

YPR006C YPR026W YPR160W YPR184W 02.45.15 Generación de energía

(ej. ATP sintasa) 1.65E-08 YBR039W YDL004W YDL130W-A YDL181W YDR377W YGR008C YKL016C YLR295C YML081C-A YOL077W-A

YOR065W YPL078C YPL271W YPR020W 14 21

01.05.02 Metabolismo de azúcares, glucosidos, polioles y

carboxilatos 1.17E-07

YBR001C YBR117C YBR299W YDR148C YDR178W YGL156W YGR043C YGR244C YGR287C YHR104W YIL107C YIL162W

YJL153C YJL155C YKL085W YKL141W YKL148C YLL041C YLR070C YML100W YMR105C YNL037C YNL241C YNR001C

YOR136W YOR347C YPL262W YPR001W YPR026W

29 81

01.05.02.07 Catabolismo de azúcares, glucosidos, polioles y

YBR001C YBR117C YBR299W YDR148C YDR178W YGL156W YGR043C YGR244C YGR287C YHR104W YIL107C YIL162W

YJL155C YKL085W YKL141W YKL148C YLL041C YLR070C YMR105C YNL037C YNL241C YNR001C YOR136W YOR347C

YPL262W YPR001W YPR026W

27 79

01 METABOLISMO 9.97E-07 YAL005C YAL017W YAL039C YAL054C YAL061W YBL015W YBL021C YBL033C YBR001C YBR006W YBR026C YBR050C YBR117C YBR132C YBR177C YBR204C YBR214W YBR222C YBR284W YBR293W YBR294W YBR297W YBR299W YCL040W

YCR079W YCR091W YCR105W YCR107W YDL079C YDL124W YDL159W YDL168W YDL174C YDL194W YDL205C YDL214C YDL215C YDL243C YDL244W YDL246C YDR009W YDR018C YDR036C YDR043C YDR074W YDR096W YDR148C YDR178W YDR204W YDR216W YDR221W YDR242W YDR247W YDR248C

YDR253C YDR277C YDR313C YDR403W YDR406W YDR421W

252 1514

(4)

YDR436W YDR453C YDR513W YDR530C YEL011W YEL020C YEL041W YER015W YER026C YER035W YER047C YER054C YER062C YER069W YER096W YER141W YER175C YFL010W-A

YFL014W YFL030W YFL060C YFL061W YFR003C YFR030W YFR053C YGL037C YGL059W YGL062W YGL125W YGL134W YGL154C YGL156W YGL158W YGL180W YGL184C YGL205W YGL222C YGL227W YGL248W YGL254W YGR019W YGR028W

YGR032W YGR043C YGR052W YGR161C YGR183C YGR244C YGR247W YGR256W YGR287C YHL020C YHL022C YHL032C YHR018C YHR033W YHR037W YHR104W YHR106W YHR112C

YHR176W YIL042C YIL045W YIL050W YIL099W YIL107C YIL113W YIL155C YIL160C YIL162W YIR017C YIR029W YIR032C YIR038C YJL088W YJL100W YJL137C YJL141C YJL153C

YJL155C YJL164C YJR019C YJR059W YJR073C YJR103W YJR109C YJR130C YJR149W YJR155W YKL038W YKL055C YKL085W YKL109W YKL141W YKL148C YKL150W YKL171W YKL188C YKL209C YKL218C YKR034W YKR058W YKR067W YKR097W YLL010C YLL013C YLL019C YLL041C YLL057C YLR070C YLR134W YLR142W YLR205C YLR251W YLR258W YLR345W YML042W YML054C YML100W YML131W YMR020W YMR081C YMR101C YMR105C YMR156C YMR173W YMR207C YMR250W YMR271C YMR280C YMR291W YMR302C YMR303C YMR306W YMR311C YMR322C YMR323W YNL009W YNL037C YNL128W YNL134C YNL202W YNL241C YNL250W YNL274C YNL277W YNL331C YNR001C YNR002C YNR056C YNR058W YNR071C YOL058W YOL100W YOL108C YOL132W YOL151W YOR040W YOR054C YOR100C YOR120W YOR136W YOR178C YOR237W YOR245C YOR303W YOR317W YOR347C YOR351C YOR358W YOR374W YOR388C YPL004C YPL017C YPL026C

YPL052W YPL057C YPL061W YPL087W YPL113C YPL123C YPL135W YPL201C YPL236C YPL240C YPL262W YPR001W

YPR002W YPR006C YPR026W YPR160W YPR184W 02.10 Ciclo de los ácidos

tricarboxílicos 1.73E-06 YDL215C YDR148C YDR178W YGR244C YKL085W YKL141W YKL148C YLL041C YMR118C YNL009W YNL037C YNR001C

YOR136W YPL262W YPR001W 15 31

02.45 Conservación de energía y

regeneración 3.37E-06 YAL054C YBR039W YDL004W YDL130W-A YDL181W YDR377W YEL020C YGR008C YKL016C YLR295C YML081C-A YNL009W

YOL077W-A YOR065W YPL078C YPL171C YPL271W YPR020W 18 44

(5)

02.01 Glucolisis y

gluconeogénesis 7.34E-06

YBR105C YCL040W YCR105W YDR255C YEL012W YFR053C YGL062W YGL227W YIL097W YIL107C YJL089W YJL155C YKR097W YLR345W YMR105C YMR280C YMR323W YNL134C

YNL241C YOL151W YOR347C

21 59

02.19 Metabolismo de las reservas energéticas (ej.

glucógeno, trehalosa) 1.14E-05

YBR001C YBR299W YDR074W YEL011W YER054C YFR003C YGL134W YGR032W YGR287C YIL045W YJL137C YKR058W YLR258W YML100W YMR105C YOR178C YPL240C YPR026W

YPR160W YPR184W

20 56

02.16 Fermentación 4.29E-05 YAL054C YAL061W YCR105W YCR107W YDL085W YDL174C YDL243C YJR155W YLR134W YML054C YMR145C YMR303C

YNL331C YOR374W YOR388C YPL061W YPR006C 17 47 16.21 Uniòn del complejo

cosubstrato, cofactor, vitamina 7.47E-05

YDL124W YDR178W YFR030W YGL125W YGR256W YHR106W YHR176W YJL153C YKL141W YKL148C YKL150W YKL218C YLL041C YLR070C YLR205C YNL009W YNL037C YOR136W

YPL171C

19 58

01.01.03 Asimilación de amonio;

metabolismo del grupo glutamato 1.65E-04 YBR006W YBR293W YDL215C YER069W YHR018C YHR037W YJL088W YJR109C YLR142W YMR250W YNL037C YNL241C

YNR001C YOL058W YOR136W YOR303W 16 47

02.01.03 Regulación de glucolisis

y gluconeogénesis 2.72E-04 YBR105C YDR255C YEL012W YFR053C YGL227W YIL097W

YIL107C YJL089W YJL155C 9 19

32.01.01 Respuesta a estrés

oxidativo 3.89E-04 YBL064C YBR006W YCR083W YDR256C YDR453C YDR513W YFL014W YGR088W YHR008C YHR106W YIR038C YKL026C

YKL086W YKL150W YKR049C YMR250W YOL151W 17 55

10.03.02 Meiosis 5.97E-04

YBR186W YBR214W YCL048W YDL114W YDR055W YDR273W YER044C-A YER106W YFL003C YGL033W YGL045W YGL090W YGL158W YGL163C YGL194C YGR044C YGR225W YGR247W YHL022C YHL024W YHR124W YHR157W YKR046C YML128C YMR133W YNL196C YNL242W YNL250W YOR177C YOR178C YOR351C YPL055C YPL130W YPL200W YPL240C YPR007C

36 161

32.01 Respuesta a estrés 6.02E-04 YAL005C YAR020C YBL064C YBR001C YBR006W YBR016W YBR054W YBR072W YBR132C YBR169C YBR173C YCR083W

YCR104W YDL059C YDL079C YDL200C YDR043C YDR059C YDR074W YDR079W YDR171W YDR231C YDR256C YDR436W

YDR453C YDR513W YDR533C YEL060C YER062C YER103W YER142C YER143W YER162C YFL014W YFL016C YFL020C YFL060C YGL163C YGL180W YGR008C YGR088W YGR249W

YHR008C YHR104W YHR106W YIL101C YIL113W YIR038C

82 450

(6)

YJL144W YKL026C YKL086W YKL150W YKL163W YKL201C YKR049C YLL010C YLL039C YML095C YML100W YMR137C YMR173W YMR201C YMR250W YMR322C YNL027W YNL077W YNL160W YNL241C YNL250W YOL052C-A YOL151W YOR028C YOR054C YOR120W YOR178C YPL004C YPL087W YPL154C

YPL240C YPR005C YPR026W YPR093C 14.07.11.01 Procesamiento

autoproteolítco 9.52E-04 YBL078C YBR128C YDL113C YDL149W YGL180W YJL036W

YLR423C YMR159C YNL242W YNR007C 10 26

14.13.04 Degradación de proteínas lisosomales y

vacuolares 9.52E-04 YBL078C YBR105C YEL060C YGL180W YGL227W YKL103C

YMR159C YNR007C YOR003W YPL154C 10 26

32.07.07 Detoxificación de ROS 9.52E-04 YBL064C YDR256C YDR453C YDR513W YGR088W YHR008C

YIR038C YKL026C YLR205C YNR064C 10 26

01.05.02.04 Anabolismo de azúcares, glucosidos, polioles y

carboxilatos 1.00E-03 YBR001C YBR117C YBR299W YGR043C YIL107C YIL162W

YJL153C YJL155C YLR070C YML100W YMR105C YPR026W 12 35 01.02 Metabolismo de N, S y Se 1.10E-03

YDL215C YDR242W YDR253C YFL010W-A YFL061W YFR030W YGL125W YGL184C YGL227W YGL254W YGR019W YHR106W

YHR112C YHR176W YIR017C YIR029W YIR032C YJR130C YJR149W YKR034W YLL057C YNR002C YOL058W YPL135W

24 97

32 RESCATE CELULAR, DEFENSA Y

VIRULENCIA 1.21E-03

YAL005C YAR020C YBL064C YBR001C YBR006W YBR016W YBR054W YBR072W YBR132C YBR169C YBR173C YBR180W

YCL073C YCR083W YCR104W YDL059C YDL079C YDL168W YDL200C YDR043C YDR059C YDR074W YDR079W YDR171W YDR231C YDR256C YDR423C YDR436W YDR453C YDR513W YDR533C YEL060C YER062C YER103W YER142C YER143W

YER162C YER185W YFL014W YFL016C YFL020C YFL060C YGL163C YGL166W YGL180W YGL254W YGR008C YGR088W

YGR249W YHR008C YHR104W YHR106W YIL101C YIL113W YIR002C YIR038C YJL144W YKL026C YKL086W YKL150W YKL163W YKL201C YKR049C YLL010C YLL039C YLL057C YLR205C YML095C YML100W YMR137C YMR173W YMR201C YMR250W YMR322C YNL027W YNL074C YNL077W YNL160W YNL241C YNL250W YNR064C YOL052C-A YOL151W YOR028C YOR031W YOR054C YOR120W YOR178C YPL004C YPL087W YPL154C YPL240C YPR005C YPR026W YPR036W-A YPR093C

96 554

01.05.03.01 Metabolismo del 1.26E-03 YJL137C YKR058W YLR258W YMR311C 4 5

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glucógeno

01.05.03.01.04 Anabolismo del

glucógeno 1.26E-03 YJL137C YKR058W YLR258W YMR311C 4 5

16.21.08 Unión de Fe/S 1.26E-03 YDR178W YKL141W YKL148C YLL041C 4 5

20.09.03 Transporte peroxisomal 1.56E-03 YDR244W YDR329C YER015W YGL153W YHR160C YKL188C

YML042W YOL044W 8 19

01.01.03.05.01 Biosíntesis de

arginina 2.15E-03 YER069W YHR018C YJL088W YJR109C YOL058W YOR303W 6 12

43.01.03.09 Desarrollo de

ascosporas 2.35E-03

YBL066C YBR180W YCL048W YDL222C YDR055W YDR059C YDR273W YDR403W YEL060C YER044C-A YER046W YER096W YGL090W YGL180W YGR032W YGR059W YGR225W YHL024W

YIL099W YLL005C YLL039C YLR054C YML066C YMR017W YNL128W YNL194C YNL196C YNL202W YNL242W YOL071W

YOR177C YPL027W YPL154C YPL240C YPR007C

35 167

01.05.06 Metabolismo de ácidos

orgánicos 2.91E-03 YAL054C YLR251W YMR303C YOR374W YPL061W 5 9

01.05.06.07 Catabolismo de

ácidos orgánicos 2.91E-03 YAL054C YLR251W YMR303C YOR374W YPL061W 5 9

01.01.03.05 Metabolismo de

arginina 3.31E-03 YBR293W YER069W YHR018C YJL088W YJR109C YLR142W

YOL058W YOR303W 8 21

10.03.02.01 Meiosis I 3.56E-03 YER044C-A YGR225W YHL022C YHR157W YMR133W

YNL250W 6 13

99 PROTEÍNAS INCLASIFICADAS 6.29E-03 YAL016C-B YAL034C YAR023C YBL049W YBL059C-A YBL059W YBL071C-B YBR046C YBR047W YBR053C YBR056W-A YBR062C YBR085C-A YBR147W YBR200W-A YBR230C YBR230W-A YBR250W YBR262C YBR269C YBR285W YBR298C-

A YCL001W-A YCL001W-B YCR082W YDL021W YDL027C YDL057W YDL091C YDL110C YDL169C YDL180W YDL183C

YDL204W YDR003W YDR003W-A YDR031W YDR034W-B YDR042C YDR070C YDR282C YDR357C YDR374C YDR379C-A YDR381C-A YDR441C YDR504C YDR540C YEL073C YER004W

YER033C YER037W YER039C-A YER078W-A YER079W YER182W YFL068W YFR011C YFR017C YFR035C YGL010W YGL041C-B YGL057C YGL081W YGL117W YGL146C YGL185C YGL250W YGL259W YGR053C YGR066C YGR110W YGR130C

YGR153W YGR154C YGR174W-A YGR196C YGR243W YGR273C YHL048C-A YHR007C-A YHR087W YHR126C

209 1393

(8)

YHR140W YHR159W YHR199C YHR199C-A YHR202W YIL055C YIL057C YIL077C YIL087C YIL136W YIL152W YIR003W YIR016W YJL027C YJL037W YJL048C YJL057C YJL066C YJL077C

YJL077W-B YJL105W YJL133C-A YJL151C YJL161W YJL185C YJL217W YJR008W YJR061W YJR079W YJR080C YJR115W YKL023W YKL037W YKL071W YKL091C YKL107W YKL133C

YKL151C YKL162C YKR011C YKR015C YLR031W YLR149C YLR152C YLR264C-A YLR267W YLR281C YLR312C YLR392C

YLR406C-A YML050W YML054C-A YML083C YMR002W YMR040W YMR041C YMR090W YMR105W-A YMR110C YMR111C YMR114C YMR191W YMR194C-B YMR195W YMR196W YMR251W YNL033W YNL092W YNL100W YNL115C

YNL144C YNL155W YNL193W YNL195C YNL200C YNL208W YNL269W YNL277W-A YNL279W YNL295W YNL305C YNR014W YNR034W-A YNR068C YOL083W YOL084W YOL131W YOL154W YOL155W-A YOR011W-A YOR020W-A YOR032W-A YOR052C YOR059C YOR062C YOR152C YOR161C YOR173W YOR186W

YOR192C-C YOR214C YOR220W YOR289W YOR365C YOR376W-A YOR389W YOR394W YPL054W YPL107W YPL109C

YPL119C-A YPL186C YPL189C-A YPL222W YPL229W YPL260W YPL277C YPL278C YPR061C YPR098C YPR116W YPR117W

YPR127W YPR159C-A 01.01.03.02 Metabolismo del

glutamato 6.30E-03 YBR006W YDL215C YHR037W YLR142W YMR250W YNL037C

YNR001C YOR136W 8 23

grasos 8.40E-03 YBR026C YDR036C YGL205W YIL160C YJR019C YKL055C

YMR207C YNL009W 8 24

18.02.01.02 Inhibidor enzimático 1.11E-02 YDL181W YFR003C YHR138C YJL157C YLR178C YNL015W

YOR054C YPL004C YPL024W YPL052W 10 35

20.01.03 Transporte de

carbohidratos y compuestos del C 1.29E-02 YBR241C YCL040W YDL199C YDR277C YDR342C YDR497C YDR536W YFL011W YJL214W YJL219W YKL038W YKL217W

YML042W YPL026C YPL134C 15 63

16.21.07 Unión de NAD/NADP 1.36E-02 YDL124W YFR030W YGL125W YGR256W YHR106W YJL153C

YLR070C YNL009W YNL037C YOR136W 10 36

monosacáridos secundarios 1.68E-02 YJL153C YLR070C 2 2

32.07.07.01 Reacción de la

catalasa 1.68E-02 YDR256C YGR088W 2 2

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18.02.01.02.03 Inhibidor de

proteasas 1.77E-02 YHR138C YLR178C YNL015W 3 5

02.16.01 Fermentación alcohólica 1.90E-02 YDL085W YLR134W YMR145C YMR303C YOR374W 5 13 02.25 Oxidación de ácidos grasos 2.06E-02 YGL205W YIL160C YJR019C YNL202W 4 9

14.13 Degradación de péptidos y

proteínas 2.84E-02

YBL078C YBR105C YBR128C YBR139W YBR170C YBR173C YBR214W YCL044C YCR045C YDL020C YDL079C YDR059C YDR306C YDR313C YDR330W YEL012W YEL059C-A YEL060C

YER047C YER143W YFL016C YFL044C YGL141W YGL180W YGL227W YGL240W YGR048W YGR225W YHL030W YHR138C

YJL036W YKL103C YKL171W YLL039C YLR178C YLR423C YMR159C YMR304W YNL015W YNR007C YNR069C YOR003W

YPL154C YPR151C

44 256

glutamina 3.21E-02 YJR109C YNL241C YOR303W 3 6

01.01.05.03 Ciclo de la urea 3.21E-02 YHR018C YJL088W YOL058W 3 6

01.01.03.02.01 Biosíntesis de

glutamato 3.56E-02 YHR037W YLR142W YNL037C YNR001C YOR136W 5 15

01.01.05 Metabolismo de urea,

creatina y poliaminas 3.56E-02 YHR018C YJL088W YMR020W YOL058W YPL052W 5 15

32.01.05 Respuesta al choque

térmico 3.63E-02 YFL014W YHR104W YOL151W YOR178C YPL004C YPL087W 6 20

01.20 Metabolismo secundario 3.99E-02 YAL039C YDL205C YDR204W YDR453C YER069W YHR104W YHR176W YJL088W YJL153C YKL218C YLR070C YLR205C

YML042W YMR323W YOL058W YOR120W 16 78

aminoácidos 4.35E-02

YBR006W YBR117C YBR293W YBR294W YCR107W YDL215C YDL243C YDR253C YDR421W YER069W YFL010W-A YFL030W

YFR030W YGL125W YGL154C YGL184C YGR019W YHR018C YHR033W YHR037W YHR112C YIL042C YIR017C YJL088W YJR109C YJR130C YJR155W YLR142W YMR020W YMR250W YNL037C YNL241C YNL277W YNL331C YNR001C YOL058W

YOR040W YOR136W YOR303W YPL052W YPR006C

41 243

14.13.04.02 Degradación de

proteínas vacuolares 4.37E-02 YEL060C YGL227W YKL103C YPL154C 4 11

32.07 Detoxificación 4.44E-02

YBL064C YBR180W YCL073C YCR083W YDL168W YDR256C YDR423C YDR453C YDR513W YER185W YGL254W YGR088W

YHR008C YIR002C YIR038C YKL026C YLL057C YLR205C YNL241C YNR064C YOL151W YOR031W

22 117

(10)

purinas y nucleótidos 4.61E-02 YDR530C YIR029W 2 3

01.20.01 Metabolismo de

derivados de aúcares primarios 4.61E-02 YJL153C YLR070C 2 3

tirosina 4.65E-02 YBR006W YCR107W YDL243C YJR155W YNL331C 5 16

B

02 ENERGÍA 2.87E-26 YAL054C YAL061W YAL062W YBL030C YBL045C YBL080C YBR001C YBR026C YBR039W YBR105C YBR117C YBR299W YCL040W YCR105W YCR107W YDL067C YDL130W-A YDL174C

YDL181W YDL215C YDL243C YDR079W YDR148C YDR178W YDR231C YDR255C YDR377W YDR511W YDR529C YEL011W YEL012W YEL020C YEL024W YEL039C YER054C YER065C YER141W YFL030W YFR033C YFR053C YGL062W YGL134W YGL187C YGL191W YGL205W YGL226W YGL227W YGR032W

YGR043C YGR087C YGR174C YGR183C YGR244C YGR248W YGR256W YGR287C YHR001W-A YHR051W YHR116W YIL017C YIL045W YIL097W YIL107C YIL155C YIL160C YJL089W YJL137C

YJL155C YJL166W YJR019C YJR048W YJR155W YKL016C YKL085W YKL093W YKL141W YKL148C YKL150W YKR009C

YKR016W YKR046C YKR058W YLL041C YLR038C YLR132C YLR174W YLR258W YLR295C YLR345W YML054C YML081C-A YML087C YML100W YML120C YMR030W YMR081C YMR105C YMR118C YMR135C YMR145C YMR169C YMR170C YMR188C YMR244W YMR256C YMR280C YMR323W YNL009W YNL037C YNL052W YNL117W YNL134C YNL202W YNL237W YNL241C YNR001C YOL151W YOR065W YOR136W YOR178C YOR347C

137 367

(11)

YOR356W YOR374W YOR388C YPL061W YPL078C YPL171C YPL219W YPL240C YPL262W YPR001W YPR006C YPR020W

YPR026W YPR160W YPR184W YPR191W

YBL045C YBR039W YDL067C YDL130W-A YDL181W YDR178W YDR231C YDR377W YDR529C YEL024W YEL039C YFR033C YGL187C YGL191W YGR183C YHR001W-A YHR051W YJL166W

YJR048W YKL016C YKL141W YKL148C YKL150W YLL041C YLR038C YLR295C YML054C YML081C-A YML120C YMR145C YMR256C YNL052W YOR065W YPL078C YPR020W YPR191W

36 61

02.13 Respiración 1.47E-13

YBL030C YBL045C YBL080C YBR026C YBR039W YDL067C YDL130W-A YDL174C YDR079W YDR178W YDR231C YDR377W

YDR529C YEL024W YEL039C YER141W YFR033C YGL187C YGL191W YGL226W YGR174C YGR183C YHR001W-A YHR051W

YHR116W YIL155C YJL166W YJR048W YKL016C YKL093W YKL141W YKL148C YKL150W YKR016W YKR046C YLL041C YLR038C YLR132C YLR295C YML054C YML081C-A YML087C YML120C YMR030W YMR081C YMR145C YMR188C YMR244W YMR256C YNL052W YNL237W YOR065W YOR356W YOR374W

YPL078C YPR020W YPR191W

57 138

YBL030C YBL045C YBL080C YBR026C YDL067C YDL174C YDR079W YDR178W YDR231C YDR529C YEL024W YFR033C YGL187C YGL191W YGR183C YHR001W-A YHR051W YHR116W

YJL166W YKL093W YKL141W YKL148C YKR046C YLL041C YLR038C YLR132C YML120C YMR030W YMR081C YMR145C

YMR188C YMR256C YNL052W YOR065W YPR191W

35 77

carbohidratos y compuestos del C 1.37E-09

YAL017W YAL054C YAL061W YAR071W YBL015W YBL021C YBR001C YBR050C YBR093C YBR117C YBR297W YBR299W YCL040W YCR105W YCR107W YDL024C YDL086W YDL124W YDL168W YDL174C YDL194W YDL243C YDL246C YDR009W YDR036C YDR043C YDR148C YDR178W YDR216W YDR248C

YDR277C YDR502C YDR511W YEL011W YEL020C YEL070W YER024W YER054C YER065C YER096W YER175C YFL014W YFR053C YGL062W YGL125W YGL134W YGL156W YGR019W YGR032W YGR043C YGR087C YGR194C YGR244C YGR256W YGR287C YHL032C YHR043C YHR044C YHR104W YHR210C YIL045W YIL050W YIL099W YIL107C YIL154C YIL155C YIL162W

YJL137C YJL153C YJL155C YJL218W YJR096W YJR155W YKL038W YKL085W YKL109W YKL141W YKL148C YKR058W

128 505

(12)

YLL041C YLR070C YLR174W YLR251W YLR258W YLR345W YML054C YML100W YMR020W YMR105C YMR169C YMR170C

YMR280C YMR311C YMR323W YNL009W YNL037C YNL063W YNL117W YNL134C YNL241C YNL274C YNR001C YNR002C YNR071C YOL132W YOR040W YOR120W YOR136W YOR178C

YOR190W YOR347C YOR358W YOR374W YOR388C YPL017C YPL026C YPL057C YPL061W YPL113C YPL201C YPL219W YPL262W YPR001W YPR002W YPR006C YPR026W YPR160W

YPR184W

01.05.02 Metabolismo de azúcares, glucosidos, polioles y

YBR001C YBR117C YBR299W YDR148C YDR178W YGL156W YGR043C YGR194C YGR244C YGR287C YHR104W YIL107C

YIL162W YJL153C YJL155C YJR096W YKL085W YKL141W YKL148C YLL041C YLR070C YML100W YMR105C YNL037C YNL241C YNR001C YOR136W YOR347C YPL262W YPR001W

YPR026W

31 81

02.10 Ciclo de los ácidos

tricarboxílicos 4.59E-07 YAL062W YDL215C YDR148C YDR178W YGR244C YKL085W YKL141W YKL148C YLL041C YLR174W YMR118C YNL009W

YNL037C YNR001C YOR136W YPL262W YPR001W 17 31 01 METABOLISMO 1.69E-06 YAL005C YAL017W YAL039C YAL054C YAL061W YAL062W

YAR071W YBL015W YBL016W YBL021C YBL033C YBR001C YBR006W YBR026C YBR050C YBR093C YBR117C YBR132C YBR177C YBR183W YBR204C YBR214W YBR222C YBR284W YBR293W YBR294W YBR297W YBR299W YCL040W YCR079W

YCR091W YCR105W YCR107W YDL024C YDL045C YDL079C YDL086W YDL124W YDL159W YDL168W YDL174C YDL194W

YDL205C YDL214C YDL215C YDL230W YDL243C YDL244W YDL246C YDR009W YDR018C YDR036C YDR043C YDR061W YDR096W YDR148C YDR178W YDR204W YDR216W YDR242W

YDR247W YDR248C YDR258C YDR277C YDR313C YDR402C YDR403W YDR406W YDR421W YDR436W YDR453C YDR490C YDR492W YDR502C YDR511W YDR513W YDR523C YDR530C

YEL011W YEL020C YEL041W YEL052W YEL070W YER015W YER024W YER026C YER035W YER047C YER054C YER065C YER091C YER096W YER141W YER175C YFL010W-A YFL014W

YFL021W YFL030W YFL060C YFL061W YFR053C YGL037C YGL059W YGL062W YGL125W YGL134W YGL154C YGL156W YGL158W YGL180W YGL184C YGL205W YGL222C YGL227W YGL248W YGR019W YGR028W YGR032W YGR043C YGR052W

293 1514

(13)

YGR087C YGR161C YGR183C YGR194C YGR244C YGR247W YGR256W YGR287C YHL020C YHL022C YHL032C YHR001W YHR018C YHR033W YHR037W YHR043C YHR044C YHR104W

YHR112C YHR176W YHR190W YHR210C YIL042C YIL045W YIL050W YIL099W YIL107C YIL113W YIL154C YIL155C YIL160C

YIL162W YIR017C YIR027C YIR029W YJL088W YJL100W YJL132W YJL137C YJL141C YJL153C YJL155C YJL164C YJL218W

YJR019C YJR059W YJR073C YJR096W YJR103W YJR149W YJR155W YKL020C YKL038W YKL085W YKL087C YKL109W YKL141W YKL148C YKL150W YKL171W YKL188C YKL209C YKL218C YKR009C YKR034W YKR058W YKR089C YLL010C YLL013C YLL019C YLL026W YLL041C YLL060C YLR070C YLR142W YLR174W YLR205C YLR251W YLR258W YLR345W YML042W YML054C YML057W YML075C YML100W YML131W YMR020W YMR081C YMR096W YMR105C YMR156C YMR169C YMR170C YMR173W YMR207C YMR210W YMR250W YMR271C YMR280C YMR302C YMR311C YMR322C YMR323W YNL009W

YNL014W YNL037C YNL063W YNL117W YNL128W YNL134C YNL202W YNL231C YNL241C YNL274C YNL277W YNL314W YNR001C YNR002C YNR019W YNR041C YNR058W YNR071C YOL058W YOL100W YOL108C YOL132W YOL151W YOR040W YOR054C YOR100C YOR120W YOR136W YOR178C YOR180C YOR190W YOR237W YOR245C YOR303W YOR313C YOR317W

YOR347C YOR356W YOR358W YOR374W YOR388C YPL004C YPL017C YPL026C YPL033C YPL057C YPL061W YPL087W

YPL095C YPL113C YPL117C YPL123C YPL135W YPL140C YPL147W YPL201C YPL203W YPL219W YPL236C YPL240C YPL262W YPR001W YPR002W YPR006C YPR026W YPR065W

YPR078C YPR160W YPR184W 01.05.02.07 Catabolismo de

azúcares, glucosidos, polioles y

YBR001C YBR117C YBR299W YDR148C YDR178W YGL156W YGR043C YGR194C YGR244C YGR287C YHR104W YIL107C

YIL162W YJL155C YJR096W YKL085W YKL141W YKL148C YLL041C YLR070C YMR105C YNL037C YNL241C YNR001C

YOR136W YOR347C YPL262W YPR001W YPR026W

29 79

20.01.15 Transporte de electrones 9.00E-06 YBR039W YCR083W YDL067C YDL130W-A YDL181W YDR178W YDR377W YDR513W YEL039C YGL187C YGL191W YHR051W

YJR048W YKL016C YKL141W YKL148C YKL150W YLL041C YLR038C YLR295C YML081C-A YML130C YMR145C YMR256C

29 83

(14)

YNL052W YOR065W YPL078C YPL171C YPR020W 02.01 Glicolisis y gluconeogénesis 9.72E-06

YBR105C YCL040W YCR105W YDR255C YDR511W YEL012W YFR053C YGL062W YGL227W YIL017C YIL097W YIL107C YJL089W YJL155C YLR345W YMR105C YMR135C YMR280C

YMR323W YNL134C YNL241C YOL151W YOR347C

23 59

02.01.03 Regulación de glicolisis y

gluconeogénesis 2.66E-05 YBR105C YDR255C YEL012W YFR053C YGL227W YIL017C

YIL097W YIL107C YJL089W YJL155C YMR135C 11 19 20.01.03 Transporte de

carbohidratos y compuestos del C 1.09E-04

YBR241C YBR298C YCL040W YDL199C YDR277C YDR342C YDR497C YDR536W YEL069C YER024W YFL011W YFL040W

YJL214W YJL219W YKL038W YKL217W YML042W YML123C YNL318C YNR072W YPL026C YPL134C

22 63

16.21 Unión del complejo

cosubstrato/cofactor/vitamina 2.69E-04

YDL124W YDR178W YGL125W YGR256W YHR176W YJL153C YKL141W YKL148C YKL150W YKL218C YLL041C YLR070C YLR174W YLR205C YML075C YNL009W YNL037C YNL234W

YOR136W YPL171C

20 58

32.01 Respuesta a estrés 3.90E-04

YAL005C YAR020C YBL064C YBR001C YBR006W YBR016W YBR054W YBR072W YBR093C YBR132C YBR169C YCR021C YCR083W YCR104W YDL079C YDR043C YDR059C YDR079W YDR171W YDR214W YDR231C YDR256C YDR258C YDR436W YDR453C YDR513W YDR533C YEL039C YEL049W YEL060C YER095W YER103W YER142C YER143W YER162C YFL014W

YFL016C YFL020C YFL060C YGL128C YGL163C YGL180W YGR088W YGR249W YHR008C YHR043C YHR104W YIL101C

YIL113W YJL144W YKL020C YKL026C YKL086W YKL150W YKL163W YKL201C YKR049C YLL010C YLL026W YLL039C YLL060C YLR216C YML058W-A YML100W YMR096W YMR137C YMR169C YMR173W YMR174C YMR175W YMR201C YMR250W YMR322C YNL007C YNL077W YNL160W YNL234W YNL241C YOL052C-A YOL151W YOR009W YOR010C YOR027W YOR028C

YOR054C YOR120W YOR178C YPL004C YPL087W YPL140C YPL196W YPL223C YPL240C YPR005C YPR026W YPR093C

96 450

02.19 Metabolismo de reservas energéticas (ej. glicógeno,

trehalosa) 4.81E-04

YBR001C YBR299W YEL011W YER054C YGL134W YGR032W YGR287C YIL045W YJL137C YKR058W YLR258W YML100W YMR105C YOR178C YPL219W YPL240C YPR026W YPR160W

YPR184W

19 56

02.45.15 Generación de energía

(ej. ATP sintasa) 5.24E-04 YBR039W YDL130W-A YDL181W YDR377W YKL016C YLR295C

YML081C-A YOR065W YPL078C YPR020W 10 21

(15)

10.03.02 Meiosis 6.19E-04

YBR186W YBR214W YDL114W YDR055W YDR218C YDR523C YER044C-A YER095W YER106W YFL003C YGL033W YGL045W

YGL090W YGL158W YGL163C YGL194C YGR044C YGR225W YGR247W YHL022C YHL024W YHR079C-A YHR124W YHR157W

YJR021C YKR046C YLR329W YML128C YMR133W YNL196C YNL242W YOR177C YOR178C YOR313C YPL033C YPL055C

YPL130W YPL200W YPL240C YPR007C YPR078C

41 161

99 PROTEÍNAS INCLASIFICADAS 6.72E-04 YAL016C-B YAL018C YAL034C YAL046C YAL065C YAR023C YBL049W YBL108C-A YBR046C YBR047W YBR053C YBR056W-

A YBR085C-A YBR147W YBR157C YBR184W YBR200W-A YBR230C YBR250W YBR262C YBR269C YBR270C YBR280C

YBR285W YCL021W-A YCL026C-B YCL036W YDL021W YDL027C YDL057W YDL091C YDL110C YDL123W YDL139C YDL169C YDL180W YDL183C YDL186W YDL204W YDL218W

YDR003W YDR003W-A YDR031W YDR034W-B YDR042C YDR070C YDR246W-A YDR262W YDR282C YDR374C YDR379C-A YDR381C-A YDR441C YDR475C YDR504C YDR525W-A YDR540C YEL035C YEL073C YER033C YER037W

YER039C-A YER053C-A YER078W-A YER079W YER093C-A YER158C YER182W YER186C YFL012W YFL041W-A YFL068W

YFR007W YFR011C YFR017C YFR032C YFR035C YGL010W YGL041C-B YGL057C YGL081W YGL101W YGL117W YGL146C YGL185C YGL250W YGL258W-A YGL259W YGR021W YGR053C

YGR066C YGR102C YGR110W YGR146C YGR149W YGR154C YGR174W-A YGR243W YGR273C YHL021C YHL042W YHL044W

YHL048C-A YHR007C-A YHR049W YHR087W YHR126C YHR140W YHR159W YHR198C YHR199C YHR199C-A YHR202W

YIL055C YIL077C YIL087C YIL102C YIL136W YIL152W YIL165C YIR003W YIR014W YIR016W YIR018C-A YJL037W YJL038C

YJL048C YJL057C YJL066C YJL077W-B YJL082W YJL105W YJL133C-A YJL147C YJL151C YJL161W YJL163C YJL185C YJL213W YJL217W YJR005C-A YJR008W YJR061W YJR079W YJR100C YJR115W YKL023W YKL037W YKL050C YKL071W YKL094W YKL107W YKL121W YKL133C YKL151C YKL162C YKR005C YKR011C YKR015C YKR017C YKR071C YLL025W YLL056C YLR012C YLR037C YLR053C YLR108C YLR149C YLR152C YLR162W-A YLR267W YLR307C-A YLR312C YLR326W

YML050W YML054C-A YML083C YMR002W YMR040W

255 1393

(16)

YMR041C YMR085W YMR086W YMR090W YMR110C YMR111C YMR114C YMR175W-A YMR181C YMR191W YMR194C-B YMR196W YMR206W YMR251W YNL033W YNL092W YNL100W

YNL115C YNL144C YNL155W YNL193W YNL195C YNL200C YNL208W YNL269W YNL277W-A YNL279W YNL295W YNL305C YNR014W YNR034W-A YNR068C YOL032W YOL048C YOL053W YOL083W YOL084W YOL131W YOR052C YOR059C YOR062C YOR152C YOR161C YOR173W YOR192C-C YOR214C YOR215C YOR220W YOR228C YOR289W YOR338W YOR365C YOR389W YOR394W YPL005W YPL039W YPL054W YPL107W YPL109C YPL119C-A YPL159C YPL168W YPL186C YPL189C-A YPL222W

YPL229W YPL247C YPL260W YPL272C YPL277C YPL278C YPR061C YPR117W YPR127W YPR158W

02.25 Oxidación de ácidos grasos 7.52E-04 YGL205W YIL160C YJR019C YKR009C YNL202W YOR356W 6 9 14.13.04 Degradación de

proteínas lisosomales y

vacuolares 9.56E-04 YBL078C YBR105C YEL060C YGL180W YGL227W YHR195W

YKL103C YMR174C YNL223W YNR007C YOR003W 11 26 20.09.03 Transporte peroxisomal 1.05E-03 YAL055W YER015W YGL153W YHR160C YJL210W YKL188C

YML042W YOL044W YPL147W 9 19

32.01.01 Respuesta a estrés

oxidativo 1.09E-03 YBL064C YBR006W YCR083W YDR256C YDR453C YDR513W YFL014W YGR088W YHR008C YKL026C YKL086W YKL150W

YKR049C YLL060C YMR250W YOL151W YPL196W YPL223C 18 55 01.01.03.02 Metabolismo del

glutamato 1.26E-03 YAL062W YBR006W YDL215C YHR037W YLR142W YLR174W

YMR250W YNL037C YNR001C YOR136W 10 23

01.01.03 Asimilación de amonio;

metabolismo del grupo glutamato 1.27E-03 YAL062W YBR006W YBR293W YDL215C YHR018C YHR037W YJL088W YLR142W YLR174W YMR250W YNL037C YNL241C

02.16 Fermentación 1.27E-03 YAL054C YAL061W YCR105W YCR107W YDL174C YDL243C YGR087C YJR155W YML054C YMR145C YMR169C YMR170C

YOR374W YOR388C YPL061W YPR006C 16 47

02.45 Conservación de energía y

regeneración 1.76E-03 YAL054C YBR039W YDL130W-A YDL181W YDR377W YEL020C YKL016C YLR295C YML081C-A YMR170C YNL009W YOR065W

YPL078C YPL171C YPR020W 15 44

grasos 1.87E-03 YBR026C YDR036C YGL205W YIL160C YJR019C YKR009C

YMR207C YMR210W YNL009W YOR180C 10 24

01.05.03.01 Metabolismo del 2.51E-03 YJL137C YKR058W YLR258W YMR311C 4 5

(17)

glucógeno

01.05.03.01.04 Anabolismo del

glucógeno 2.51E-03 YJL137C YKR058W YLR258W YMR311C 4 5

18.02.01.02.03 Inhibidor de

proteasas 2.51E-03 YHR138C YLR178C YMR174C YNL015W 4 5

20.01.03.01 Transporte de

azúcares 2.74E-03 YBR298C YDR277C YDR342C YEL069C YFL011W YJL214W

YJL219W YKL038W YNL318C YNR072W YPL026C 11 29 01.20 Metabolism secundario 2.88E-03

YAL039C YDL086W YDL205C YDR204W YDR453C YER024W YHR104W YHR176W YJL088W YJL153C YJR096W YKL087C YKL218C YLR070C YLR205C YML042W YMR169C YMR170C

YMR323W YNR041C YOL058W YOR120W

22 78

32 RESCATE CELULAR, DEFENSA Y

VIRULENCIA 3.29E-03

YAL005C YAR020C YBL064C YBR001C YBR006W YBR016W YBR054W YBR072W YBR093C YBR132C YBR169C YCL073C YCR021C YCR083W YCR104W YDL079C YDL168W YDR043C YDR059C YDR079W YDR171W YDR214W YDR231C YDR256C

YDR258C YDR402C YDR436W YDR453C YDR513W YDR533C YEL039C YEL049W YEL060C YER095W YER103W YER142C YER143W YER162C YER185W YFL014W YFL016C YFL020C YFL050C YFL060C YGL128C YGL163C YGL166W YGL180W YGR088W YGR249W YGR281W YHR008C YHR043C YHR104W

YIL101C YIL113W YJL144W YKL020C YKL026C YKL086W YKL150W YKL163W YKL201C YKR049C YLL010C YLL026W YLL039C YLL060C YLR205C YLR216C YML058W-A YML100W YMR096W YMR137C YMR169C YMR173W YMR174C YMR175W

YMR201C YMR250W YMR322C YNL007C YNL074C YNL077W YNL160W YNL231C YNL234W YNL241C YNR064C YOL052C-A YOL151W YOR009W YOR010C YOR027W YOR028C YOR031W YOR054C YOR120W YOR178C YPL004C YPL087W YPL140C YPL196W YPL223C YPL240C YPR005C YPR026W YPR036W-A

YPR093C

109 554

14.07.11.01 Procesamiento

autoproteolítico 3.77E-03 YBL078C YBR128C YDL113C YDL149W YGL180W YJL036W

YLR423C YNL223W YNL242W YNR007C 10 26

YKL026C YLL060C YLR205C YNR064C 10 26

01.01.03.02.01 Biosíntesis de

glutamato 4.31E-03 YAL062W YHR037W YLR142W YLR174W YNL037C YNR001C

YOR136W 7 15

(18)

01.05.02.04 Anabolismo de azúcares, glucósidos, polioles y

carboxilatos 4.71E-03 YBR001C YBR117C YBR299W YGR043C YIL107C YIL162W

YJL153C YJL155C YLR070C YML100W YMR105C YPR026W 12 35 01.05.06 C-2 Metabolismo de

ácidos orgánicos 6.46E-03 YAL054C YGR087C YLR251W YOR374W YPL061W 5 9

01.05.06.07 C-2 Catabolismo de

ácidos orgánicos 6.46E-03 YAL054C YGR087C YLR251W YOR374W YPL061W 5 9

01.03.16.03 Degradación de DNA 8.79E-03 YBR214W YGR247W YHL022C YOR313C YPL033C YPR078C 6 13 10.03.02.01 Meiosis I 8.79E-03 YER044C-A YGR225W YHL022C YHR157W YLR329W YMR133W 6 13 01.20.17.01 Metabolismo de

aminoácidos no proteicos 1.13E-02 YER024W YJL088W YML042W YMR169C YMR170C 5 10 10.01.05.03.01 Recombinación

meiótica 1.22E-02 YER044C-A YER095W YFL003C YGL183C YHL022C YHL024W

YHR079C-A YHR157W YJR021C YLR329W YML128C YMR133W 12 39 01.01.03.02.02 Degradación del

glutamato 1.31E-02 YAL062W YBR006W YMR250W 3 4

01.01.05.01.02 Degradaciñon de

poliaminas 1.31E-02 YMR020W YMR169C YMR170C 3 4

20.03.02 Transporte antiporte-

potencial electroquímico 1.39E-02 YBL030C YBR293W YBR296C YBR298C YJL094C YNR002C

YOR100C 7 18

creatina y poliaminas 1.95E-02 YHR018C YJL088W YMR020W YMR169C YMR170C YOL058W 6 15

43.01.03.09 Desarrollo de

ascosporas 2.17E-02

YDL222C YDR055W YDR059C YDR218C YDR402C YDR403W YDR523C YEL060C YER044C-A YER046W YER096W YGL090W YGL180W YGR032W YGR059W YGR225W YHL024W YHR139C YIL099W YLL039C YML066C YMR017W YNL128W YNL194C YNL196C YNL202W YNL242W YNR019W YOL071W YOR177C

YOR190W YOR255W YOR313C YPL027W YPL240C YPR007C

36 167

monosacáridos secundarios 2.40E-02 YJL153C YLR070C 2 2

16.21.01 Unión del grupo hemo 2.40E-02 YLR205C YNL234W 2 2

32.01.05 Respuesta al choque

térmico 2.57E-02 YFL014W YHR104W YOL151W YOR178C YPL004C YPL087W

YPL223C 7 20

16.09 Unión de lípidos 3.66E-02 YDL113C YHR001W YJL036W YLR178C YMR175W YPL100W 6 17 16.21.07 Unión de NAD/NADP 4.23E-02 YDL124W YGL125W YGR256W YJL153C YLR070C YLR174W 10 36

(19)

YML075C YNL009W YNL037C YOR136W

C

YBR039W YDL067C YDL130W-A YDL181W YDR178W YDR231C YDR377W YDR529C YEL024W YEL039C YFR033C YGL187C YGL191W YGR183C YHR001W-A YHR051W YIL111W YJL166W

YKL141W YKL148C YKL150W YLL041C YLR038C YML054C YML081C-A YML120C YMR145C YMR256C YNL052W YOR065W

YPR191W

31 61

02 ENERGÍA 2.60E-13

YAL054C YAL061W YAL062W YBR001C YBR039W YBR105C YCL040W YCR005C YDL067C YDL130W-A YDL181W YDL243C YDR079W YDR178W YDR231C YDR377W YDR511W YDR529C YEL011W YEL012W YEL020C YEL024W YEL039C YER054C YFL030W YFR033C YFR053C YGL062W YGL134W YGL187C YGL191W YGL205W YGL226W YGR032W YGR043C YGR174C YGR183C YGR248W YHR001W-A YHR051W YIL045W YIL097W YIL107C YIL111W YIL155C YIL160C YIL172C YJL089W YJL166W

YJR155W YKL085W YKL093W YKL141W YKL148C YKL150W YKR046C YLL041C YLR038C YLR132C YLR174W YLR345W YLR377C YML054C YML081C-A YML087C YML100W YML120C YMR030W YMR081C YMR118C YMR145C YMR188C YMR244W

YMR256C YMR280C YMR323W YNL037C YNL052W YNL134C YNL237W YNL331C YNR001C YOR065W YOR136W YOR178C YOR356W YPL061W YPR006C YPR026W YPR160W YPR184W

YPR191W

92 367

02.13 Respiración 2.01E-10 YBR039W YDL067C YDL130W-A YDR079W YDR178W YDR231C YDR377W YDR529C YEL024W YEL039C YFR033C YGL187C YGL191W YGL226W YGR174C YGR183C YHR001W-A YHR051W

44 138

(20)

YIL111W YIL155C YJL166W YKL093W YKL141W YKL148C YKL150W YKR046C YLL041C YLR038C YLR132C YML054C YML081C-A YML087C YML120C YMR030W YMR081C YMR145C

YMR188C YMR244W YMR256C YNL052W YNL237W YOR065W YOR356W YPR191W

YDL067C YDR079W YDR178W YDR231C YDR529C YEL024W YFR033C YGL187C YGL191W YGR183C YHR001W-A YHR051W

YIL111W YJL166W YKL093W YKL141W YKL148C YKR046C YLL041C YLR038C YLR132C YML120C YMR030W YMR081C YMR145C YMR188C YMR256C YNL052W YOR065W YPR191W

30 77

10.03.02 Meiosis 1.65E-05

YBR186W YCL048W YCR010C YDL114W YDL115C YDR055W YDR273W YER095W YER106W YFL003C YFL033C YGL033W YGL045W YGL090W YGL194C YGR044C YGR225W YHL022C YHL024W YHR124W YHR157W YIL072W YIL112W YJR021C YKR046C YLR329W YMR133W YNL012W YNL196C YNL242W

YOL104C YOR177C YOR178C YOR351C YPL033C YPL055C YPL130W YPR007C

38 161

20.09.03 Transporte peroxisomal 1.69E-05 YAL055W YDL065C YDR244W YGL153W YGR239C YHR160C

YKL188C YLR191W YML042W YOL044W 10 19

32.01.01 Respuesta al estrés

oxidativo 3.34E-05 YBL064C YBR006W YCR083W YDR256C YDR453C YDR513W YFL014W YGR088W YHR008C YIR038C YKL026C YKL086W

YKL150W YKR049C YLL060C YOR324C YPL188W YPL223C 18 55 01.01.03 Asimilación de amonio;

metabolismo del grupo glutamato 5.30E-05 YAL062W YBR006W YBR293W YCR005C YER069W YHR018C YHR037W YJL088W YJR109C YLR142W YLR174W YNL037C

20.01.15 Transporte electrónico 5.81E-05

YBR039W YCR083W YDL067C YDL130W-A YDL181W YDR178W YDR377W YDR513W YEL039C YGL187C YGL191W YHR051W

YIL111W YKL141W YKL148C YKL150W YLL041C YLR038C YML081C-A YMR145C YMR256C YNL052W YOR065W

23 83

42.19 Peroxisoma 9.61E-05 YAL051W YDL065C YDR216W YDR244W YDR479C YGR133W YGR239C YHR160C YLR191W YMR204C YNL242W YOL044W

YPR049C 13 35

01.01.03.02.01 Biosíntesis de

glutamato 1.10E-04 YAL062W YCR005C YHR037W YLR142W YLR174W YNL037C

YNR001C YOR136W 8 15

02.10 Ciclo de los ácidos

tricarboxílicos 1.12E-04 YAL062W YCR005C YDR178W YKL085W YKL141W YKL148C

YLL041C YLR174W YMR118C YNL037C YNR001C YOR136W 12 31 01.05 Metabolismo de 3.07E-04 YAL017W YAL054C YAL061W YAR071W YBL015W YBR001C 85 505

(21)

carbohidratos y compuestos del C

YBR018C YBR050C YBR297W YCL040W YCR005C YCR010C YDL024C YDL086W YDL124W YDL194W YDL243C YDR009W YDR043C YDR054C YDR178W YDR216W YDR277C YDR511W YEL011W YEL020C YER054C YER096W YFL014W YFR053C YGL062W YGL125W YGL134W YGL156W YGR019W YGR032W

YGR043C YIL045W YIL050W YIL099W YIL107C YIL155C YIL162W YIL172C YJL153C YJR095W YJR096W YJR155W YKL085W YKL109W YKL141W YKL148C YLL041C YLR174W YLR343W YLR345W YML054C YML100W YMR020W YMR280C

YMR306W YMR323W YNL037C YNL063W YNL134C YNL274C YNL322C YNL331C YNR001C YNR002C YOL132W YOR120W

YOR136W YOR178C YOR358W YPL017C YPL026C YPL057C YPL061W YPL201C YPR002W YPR006C YPR026W YPR160W

YPR184W 14.07.11.01 Procesamiento

autoproteolítico 4.47E-04 YBL078C YCL038C YDL113C YDL149W YGL180W YJL036W

YLR423C YNL223W YNL242W YNR007C 10 26

YIR038C YKL026C YLL060C YLR205C 10 26

carbohidratos y compuestos del C 7.38E-04 YBR241C YBR298C YCL040W YCR010C YDR277C YDR342C YDR497C YDR536W YEL069C YFL011W YJR095W YKL217W

YML042W YML123C YNL318C YPL026C YPL134C 17 63 01.01.03.02 Metabolismo del

glutamato 7.47E-04 YAL062W YBR006W YCR005C YHR037W YLR142W YLR174W

YNL037C YNR001C YOR136W 9 23

18.02.01.02.03 Inhibidor de

proteasas 8.75E-04 YHR138C YLR178C YMR174C YNL015W 4 5

01.01.03.05.01 Biosíntesis de

arginina 1.31E-03 YER069W YHR018C YJL088W YJR109C YOL058W YOR303W 6 12

arginina 1.81E-03 YBR293W YER069W YHR018C YJL088W YJR109C YLR142W

YOL058W YOR303W 8 21

10.03.02.01 Meiosis I 2.19E-03 YGR225W YHL022C YHR157W YLR329W YMR133W YOL104C 6 13 01.05.02 Metabolismo de

azúcares, glucósidos, polioles y

YBR001C YBR018C YDR178W YGL156W YGR043C YIL107C YIL162W YIL172C YJL153C YJR096W YKL085W YKL141W YKL148C YLL041C YML100W YNL037C YNR001C YOR136W

YPR026W

19 81

20.03.02 Transporte antiporte-

potencial electroquímico 3.06E-03 YBR293W YBR298C YDL210W YJL094C YJR095W YNR002C

YOR100C 7 18

(22)

99 PROTEíNAS INCLASIFICADAS 3.49E-03

YAL016C-B YAL018C YAL034C YAL044W-A YAR023C YBL049W YBR046C YBR047W YBR062C YBR085C-A YBR147W YBR157C YBR221W-A YBR230C YBR250W YBR255W YBR262C YBR270C YBR285W YCL001W-A YCL001W-B YCL012C YDL110C YDL123W

YDL139C YDL169C YDL173W YDL180W YDL183C YDR003W-A YDR034W-B YDR070C YDR262W YDR275W YDR282C YDR286C

YDR374C YDR381C-A YDR441C YDR504C YDR540C YEL073C YER004W YER033C YER037W YER039C-A YER053C-A YER078W-

A YER079W YER093C-A YER158C YFL041W-A YFL068W YFR017C YFR035C YGL010W YGL041C-B YGL057C YGL081W YGL117W YGL146C YGL185C YGL258W-A YGL262W YGR053C YGR066C YGR079W YGR102C YGR110W YGR146C YGR149W YGR174W-A YGR196C YGR204C-A YGR236C YGR243W YHL006C

YHL021C YHL044W YHL048C-A YHR007C-A YHR050W-A YHR126C YHR140W YHR199C YHR199C-A YHR202W YHR214C-

D YHR214C-E YIL024C YIL055C YIL102C YIL134C-A YIL152W YIR016W YJL037W YJL048C YJL057C YJL066C YJL077C YJL077W-

B YJL105W YJL133C-A YJL147C YJL149W YJL151C YJR005C-A YJR008W YJR011C YJR061W YJR079W YJR115W YJR151C YKL023W YKL071W YKL094W YKL107W YKL121W YKL133C

YKL151C YKR011C YLL056C YLR012C YLR030W YLR053C YLR152C YLR254C YLR267W YLR312C YLR326W YLR406C-A YLR446W YML050W YML083C YMR040W YMR075W YMR085W

YMR090W YMR105W-A YMR111C YMR175W-A YMR181C YMR187C YMR191W YMR194C-B YMR253C YNL092W YNL100W

YNL144C YNL157W YNL195C YNL208W YNL211C YNL269W YNL277W-A YNL279W YNL295W YNL305C YNR034W-A YOL053W YOL084W YOL131W YOL154W YOR032W-A YOR044W

YOR052C YOR097C YOR152C YOR173W YOR186W YOR192C-C YOR220W YOR262W YOR289W YOR338W YOR365C YOR389W YOR394W YPL038W-A YPL054W YPL099C YPL107W YPL119C-A YPL159C YPL186C YPL189C-A YPL229W YPL260W YPL277C

YPL278C YPR061C YPR117W YPR127W

194 1393

01.02 Metabolismo de N, S y Se 3.92E-03

YAL062W YCR010C YDL210W YDR242W YDR253C YFL021W YGL125W YGL184C YGR019W YHR112C YHR176W YIR017C YIR029W YJR130C YJR149W YKR034W YLL057C YNL314W

YNR002C YOL058W YPL135W

21 97

43.01.03.09 Desarrollo de 6.52E-03 YBR180W YCL048W YDR055W YDR059C YDR273W YDR402C 31 167

(23)

ascosporas

YDR403W YEL060C YER020W YER046W YER096W YGL090W YGL180W YGR032W YGR059W YGR225W YHL024W YHR139C

YIL099W YLL039C YML066C YMR017W YNL012W YNL128W YNL194C YNL196C YNL242W YOR177C YOR255W YPL154C

YPR007C

02.01 Glicolisis y gluconeogénesis 7.47E-03 YBR105C YCL040W YDR511W YEL012W YFR053C YGL062W YIL097W YIL107C YJL089W YLR345W YLR377C YMR280C

YMR323W YNL134C 14 59

14.13.04 Degradación de proteínas lisosomales y

vacuolares 8.13E-03 YBL078C YBR105C YEL060C YGL180W YMR174C YNL223W

YNR007C YPL154C 8 26

01.05.02.07 Catabolismo de azúcares, glucósidos, polioles y

carboxilatos 9.53E-03 YBR001C YBR018C YDR178W YGL156W YGR043C YIL107C YIL162W YIL172C YJR096W YKL085W YKL141W YKL148C

YLL041C YNL037C YNR001C YOR136W YPR026W 17 79 18.01.07 Regulación de la

unión/disociación 1.08E-02 YFL026W YHR138C YKL178C YMR174C YNL015W YPL052W

YPR040W 7 22

10.01.05.03.01 Recombinación

meiótica 1.29E-02 YER095W YFL003C YGL183C YHL022C YHL024W YHR157W

YJR021C YLR329W YMR133W YPL164C 10 39

32.07.07.03 Reacción de

conjugación del glutation 1.37E-02 YDR513W YIR038C YLL060C 3 5

16.21 Unión del complejo

cosubstrato/cofactor/vitamina 1.58E-02 YDL124W YDR178W YGL125W YHR176W YJL153C YKL141W YKL148C YKL150W YLL041C YLR174W YLR205C YNL037C

YOR136W 13 58

20.03.02.03 Antiporte 1.82E-02 YBR293W YJL094C YJR095W YNR002C YOR100C 5 14

02.01.03 Regulación de glucolisis

y gluconeogénesis 1.86E-02 YBR105C YEL012W YFR053C YIL097W YIL107C YJL089W 6 19

01 METABOLISMO 1.95E-02

YAL017W YAL039C YAL051W YAL054C YAL061W YAL062W YAR071W YBL015W YBL033C YBL071W-A YBR001C YBR006W

YBR018C YBR050C YBR132C YBR204C YBR293W YBR297W YCL040W YCR005C YCR010C YCR079W YDL010W YDL024C YDL086W YDL124W YDL159W YDL194W YDL205C YDL210W

YDL214C YDL243C YDL244W YDR009W YDR018C YDR043C YDR054C YDR096W YDR123C YDR178W YDR216W YDR242W YDR247W YDR253C YDR277C YDR402C YDR403W YDR421W YDR436W YDR453C YDR511W YDR513W YDR530C YEL011W

202 1514

(24)

YEL020C YEL041W YER035W YER054C YER069W YER091C YER096W YFL014W YFL021W YFL030W YFL033C YFL060C YFR053C YGL062W YGL125W YGL134W YGL156W YGL180W YGL184C YGL205W YGL222C YGL248W YGR019W YGR028W YGR032W YGR043C YGR052W YGR161C YGR183C YHL020C YHL022C YHR018C YHR033W YHR037W YHR112C YHR176W YIL042C YIL045W YIL046W YIL050W YIL066C YIL099W YIL107C YIL113W YIL155C YIL160C YIL162W YIL172C YIR017C YIR029W YIR038C YJL088W YJL132W YJL141C YJL153C YJR073C YJR095W

YJR096W YJR103W YJR109C YJR130C YJR149W YJR155W YKL085W YKL109W YKL141W YKL148C YKL150W YKL171W

YKL188C YKL209C YKR034W YLL010C YLL013C YLL019C YLL041C YLL057C YLL060C YLR142W YLR151C YLR174W YLR205C YLR343W YLR345W YLR377C YML042W YML054C YML100W YML131W YMR009W YMR020W YMR036C YMR081C

YMR101C YMR173W YMR271C YMR280C YMR302C YMR306W YMR322C YMR323W YNL012W YNL037C YNL063W YNL128W

YNL134C YNL274C YNL277W YNL314W YNL322C YNL325C YNL331C YNR001C YNR002C YNR058W YNR070W YOL058W YOL132W YOR054C YOR100C YOR120W YOR136W YOR178C YOR237W YOR245C YOR303W YOR317W YOR351C YOR356W

YOR358W YPL017C YPL026C YPL033C YPL052W YPL057C YPL061W YPL087W YPL123C YPL135W YPL140C YPL188W YPL201C YPL236C YPR002W YPR006C YPR026W YPR160W

YPR184W 11.02.03.04.01 Activación de la

transcripción 2.16E-02 YAL032C YAL051W YDL020C YFL021W YIR017C YKL109W

YNL314W YOR358W YPL138C YPL181W 10 42

32.01 Respuesta a estrés 2.38E-02 YBL064C YBR001C YBR006W YBR016W YBR072W YBR132C YCR083W YDR043C YDR059C YDR079W YDR231C YDR256C YDR436W YDR453C YDR513W YDR533C YEL039C YEL060C

YER095W YER142C YER162C YFL014W YFL033C YFL060C YGL128C YGL180W YGR088W YHR008C YIL101C YIL113W YIR038C YKL026C YKL086W YKL150W YKL163W YKL201C YKR049C YLL010C YLL039C YLL060C YML058W-A YML095C YML100W YMR137C YMR173W YMR174C YMR175W YMR201C YMR322C YNL027W YNL077W YNL160W YOL052C-A YOL089C YOR028C YOR054C YOR120W YOR178C YOR324C YPL087W

YPL140C YPL154C YPL188W YPL223C YPR005C YPR026W

67 450

(25)

YPR093C 01.01.05 Metabolismo de la urea,

creatina y poliaminas 2.47E-02 YHR018C YJL088W YMR020W YOL058W YPL052W 5 15

01.01.05.03 Ciclo de la urea 2.49E-02 YHR018C YJL088W YOL058W 3 6

18.01 regulation by 2.51E-02 YFL026W YHR138C YIL113W YKL178C YMR036C YMR174C

YNL015W YPL052W YPR040W 9 37

02.19 Metabolismo de reservas energéticas (ej. glucógeno,

trehalosa) 2.78E-02 YBR001C YEL011W YER054C YGL134W YGR032W YIL045W

YIL172C YML100W YOR178C YPR026W YPR160W YPR184W 12 56 02.45.15 Generación de energía

(ej. ATP sintasa) 3.04E-02 YBR039W YDL130W-A YDL181W YDR377W YML081C-A

YOR065W 6 21

aminoácidos y derivados 3.40E-02 YBR132C YBR293W YDL210W YKL124W YKL146W YKR039W

YNL270C YOR100C YOR348C YPL134C 10 45

01.20 Metabolismo secundario 3.73E-02 YAL039C YBL071W-A YDL086W YDL205C YDR453C YER069W YHR176W YJL088W YJL153C YJR096W YLR205C YML042W

YMR323W YOL058W YOR120W 15 78

purinas y nucleótidos 3.85E-02 YDR530C YIR029W 2 3

20.03.02.02.01 Simporte

protónico 3.85E-02 YBR298C YDL210W 2 3

20.03.02.03.01 Antipote

protónico 3.98E-02 YBR293W YJL094C YNR002C 3 7

30.05.02 Ruta de señalización mediada por receptor no

enzimático 3.98E-02 YDL035C YFL026W YKL178C 3 7

30.05.02.24 Ruta de señalización

acoplada a proteína G 3.98E-02 YDL035C YFL026W YKL178C 3 7

peroxidasa 3.98E-02 YDR513W YKL026C YLR205C 3 7

aminoácidos 4.09E-02

YAL062W YBR006W YBR293W YCR005C YDL243C YDR054C YDR253C YDR421W YER069W YER091C YFL030W YGL125W YGL184C YGR019W YHR018C YHR033W YHR037W YHR112C YIL042C YIL046W YIR017C YJL088W YJR109C YJR130C YJR155W

YLR142W YLR174W YMR009W YMR020W YNL037C YNL277W YNL331C YNR001C YOL058W YOR136W YOR303W YPL052W

YPR006C

38 243

(26)

01.05.02.04 Anabolismo de azúcares, glucósidos, polioles y

carboxilatos 4.74E-02 YBR001C YBR018C YGR043C YIL107C YIL162W YJL153C

YML100W YPR026W 8 35

20.01.03.01 Transporte de

azúcares 4.76E-02 YBR298C YDR277C YDR342C YEL069C YFL011W YNL318C

YPL026C 7 29

D

purinas y nucleótidos 3.06E-11

YAR015W YBR084W YCL030C YDR020C YDR408C YDR454C YER055C YGL234W YGR061C YGR204W YKL181W YKR080W YLR017W YLR058C YLR359W YLR432W YML022W YML056C YMR120C YMR217W YMR300C YNL220W YOR128C YOR184W

24 61

01.03.01.03 Anatabolismo de

purinas y nucleótidos 1.26E-10 YAR015W YCL030C YDR408C YGL234W YGR061C YGR204W YKL181W YKR080W YLR359W YLR432W YML022W YMR120C

YMR300C YNL220W YOR128C YOR184W 16 29

11.04.01 Procesamiento de

rRNA 1.08E-09

YAL033W YBL004W YCR057C YDL060W YDL148C YDL166C YDR087C YDR324C YFL002C YGR090W YGR103W YGR128C YHR148W YHR196W YHR197W YJL010C YJL033W YJL050W

YJL109C YKL014C YKL099C YKR060W YKR081C YLL008W YLR002C YLR022C YLR129W YLR186W YLR192C YLR222C YLR276C YLR409C YLR435W YMR229C YMR235C YMR290C YNL075W YNL207W YNL222W YOL021C YOL080C YOL115W

YPL012W YPL126W YPL211W

45 205

16.03 Unión de ácidos nucleicos 6.35E-09 YBL004W YBR154C YCR057C YDL051W YDL148C YDR045C YDR324C YDR489W YER007C-A YGL232W YGR090W YGR128C YGR140W YHR143W-A YHR148W YHR170W YHR196W YIR021W YJL010C YJL011C YJL080C YJL109C YJL148W YJL209W YJR063W

YKL099C YKL144C YKL205W YKR060W YKR081C YLR103C YLR129W YLR141W YLR186W YLR192C YLR222C YLR233C

61 341

(27)

YLR409C YLR448W YLR453C YMR061W YMR125W YMR229C YNL075W YNL113W YNL151C YNL175C YNL248C YNR003C YOL077C YOL115W YOL124C YOL149W YOR295W YOR340C YOR341W YPL075W YPL126W YPR010C YPR110C YPR187W 11.06.02 Modificación de tRNA 2.26E-08 YBL024W YBR061C YBR084W YDL112W YDL201W YDL219W

YDR120C YDR165W YGL232W YGR204W YJL125C YLR316C

YLR401C YNL292W YOL093W YOL124C YOR243C 17 43

nucleótidos y nucleósidos 5.94E-08

YAL021C YAR015W YBL039C YBR084W YCL030C YDL103C YDR020C YDR172W YDR408C YDR454C YEL021W YEL042W YER055C YER070W YGL234W YGR061C YGR081C YGR204W YHR128W YJL209W YJR132W YKL181W YKL216W YKR080W YLR017W YLR058C YLR359W YLR420W YLR432W YML022W YML056C YMR080C YMR120C YMR217W YMR300C YNL220W

YNL292W YOL021C YOL080C YOL115W YOL149W YOR101W YOR128C YOR184W

44 224

16.03.03 Unión de RNA 1.03E-07

YBL004W YCR057C YDL051W YDL148C YDR324C YER007C-A YGL232W YGR090W YGR128C YHR148W YHR170W YHR196W YIR021W YJL010C YJL080C YJL109C YJL209W YKL099C YKL205W

YKR060W YKR081C YLR129W YLR141W YLR186W YLR192C YLR222C YLR233C YLR409C YLR448W YMR061W YMR125W YMR229C YNL075W YNL175C YOL077C YOL124C YOL149W

YOR295W YPL126W

39 190

11.06 Modificación de RNA 6.76E-07

YBL024W YBR061C YBR084W YDL112W YDL201W YDL219W YDR120C YDR165W YGL232W YGR204W YHR148W YJL125C YLR316C YLR401C YNL075W YNL292W YOL093W YOL124C

YOR243C

19 64

11 TRANSCRIPCIÓN 7.36E-07 YAL021C YAL033W YAR008W YBL004W YBL024W YBR060C YBR061C YBR066C YBR084W YBR154C YCR020C YCR052W YCR057C YCR065W YCR087C-A YDL051W YDL060W YDL080C

YDL112W YDL148C YDL166C YDL201W YDL219W YDR045C YDR087C YDR120C YDR165W YDR252W YDR324C YDR395W

YDR501W YEL055C YER171W YFL002C YGL232W YGR090W YGR097W YGR103W YGR128C YGR200C YGR204W YHR084W YHR143W-A YHR148W YHR167W YHR170W YHR196W YHR197W

YIR021W YJL010C YJL011C YJL033W YJL050W YJL109C YJL125C YJL148W YJL209W YJR042W YJR063W YJR147W YKL014C YKL078W YKL099C YKL125W YKL144C YKL205W YKR060W

YKR079C YKR081C YKR092C YLL004W YLL008W YLL054C

133 1077

(28)

YLR002C YLR022C YLR113W YLR129W YLR131C YLR141W YLR186W YLR192C YLR222C YLR228C YLR256W YLR276C YLR316C YLR384C YLR401C YLR409C YLR435W YML010W YMR047C YMR061W YMR080C YMR125W YMR179W YMR229C

YMR235C YMR277W YMR290C YNL075W YNL113W YNL151C YNL175C YNL207W YNL222W YNL248C YNL261W YNL292W

YNR003C YOL021C YOL080C YOL093W YOL101C YOL115W YOL124C YOL149W YOR038C YOR046C YOR243C YOR295W YOR334W YOR340C YOR341W YPL012W YPL075W YPL126W YPL211W YPL254W YPR010C YPR015C YPR110C YPR187W

16 PROTEÍNAS CON FUNCIÓN DE UNIÓN O REQUERIMIENTO DE COFACTORES (estructural o catalítico)

1.47E-06

YAR033W YBL004W YBR066C YBR084W YBR154C YBR158W YCR057C YDL051W YDL060W YDL148C YDL201W YDL226C YDR045C YDR091C YDR143C YDR165W YDR252W YDR292C YDR324C YDR489W YEL013W YER007C-A YFL002C YFR009W YGL232W YGL234W YGR090W YGR128C YGR140W YGR173W YGR204W YGR285C YHR052W YHR084W YHR128W YHR133C YHR143W-A YHR148W YHR167W YHR170W YHR196W YHR204W

YIR021W YJL010C YJL011C YJL033W YJL050W YJL080C YJL085W YJL109C YJL148W YJL179W YJL209W YJR042W YJR063W YJR070C

YKL090W YKL099C YKL144C YKL154W YKL205W YKR060W YKR079C YKR080W YKR081C YKR092C YKR103W YLL008W YLL034C YLR002C YLR008C YLR032W YLR045C YLR095C YLR103C YLR129W YLR141W YLR186W YLR188W YLR192C

YLR222C YLR233C YLR276C YLR306W YLR319C YLR381W YLR397C YLR409C YLR429W YLR448W YLR453C YML086C YML094W YML103C YMR047C YMR061W YMR080C YMR125W

YMR229C YNL075W YNL113W YNL151C YNL153C YNL175C YNL248C YNL261W YNL280C YNR003C YNR050C YOL002C YOL059W YOL077C YOL090W YOL101C YOL115W YOL124C YOL149W YOR143C YOR153W YOR295W YOR340C YOR341W

YPL075W YPL126W YPL210C YPR010C YPR110C YPR187W YPR198W

129 1049

11.04 Procesamiento de RNA 1.94E-05 YAL021C YAL033W YAR008W YBL004W YCR057C YDL051W YDL060W YDL148C YDL166C YDR087C YDR324C YDR395W YFL002C YGR090W YGR103W YGR128C YHR148W YHR196W YHR197W YIR021W YJL010C YJL033W YJL050W YJL109C YJL209W

YJR042W YKL014C YKL078W YKL099C YKL205W YKR060W YKR079C YKR081C YLL008W YLR002C YLR022C YLR129W

62 436

(29)

YLR186W YLR192C YLR222C YLR276C YLR409C YLR435W YMR047C YMR061W YMR080C YMR125W YMR229C YMR235C

YMR290C YNL075W YNL207W YNL222W YOL021C YOL080C YOL115W YOL149W YOR046C YOR334W YPL012W YPL126W

YPL211W 11.02.01 Síntesis de rRNA 4.33E-05

YBR154C YEL055C YHR143W-A YJL011C YJL148W YJR063W YKL125W YKL144C YLR141W YNL113W YNL151C YNL248C YNR003C YOR295W YOR340C YOR341W YPR010C YPR110C

YPR187W

19 83

20.09.01 Transporte nuclear 6.14E-05

YDR395W YER110C YGL016W YGL241W YJL039C YJL050W YJR042W YJR132W YKR092C YLL034C YLR347C YML103C YMR047C YMR235C YMR308C YNL207W YOR160W YOR206W

YPL125W

19 85

01.05.13 Transferencia de

grupos C-1 activados 1.23E-04 YBR084W YDR408C YGR204W YKR080W YLL031C YLR058C

YLR180W YMR120C 8 20

12 SÍNTESIS PROTEICA 1.90E-04

YAL059W YBL076C YBR061C YBR079C YDL040C YDL060W YDL082W YDL148C YDL219W YDR023W YDR060W YDR091C

YDR101C YDR172W YDR211W YDR252W YFL002C YFL022C YFR009W YGL147C YGL195W YGR054W YGR094W YGR103W

YGR162W YGR264C YHR148W YHR170W YHR197W YJL125C YJL190C YJR041C YKL021C YKL078W YKL081W YKR026C YKR081C YLL008W YLL034C YLR060W YLR186W YLR192C YLR264W YLR276C YLR291C YLR448W YMR080C YMR230W

YMR235C YMR309C YNL247W YNL301C YOL077C YOL080C YOL097C YOR168W YOR206W YOR260W YOR276W YOR361C

YPL012W YPL160W YPL211W

63 480

11.02.02 Síntesis de tRNA 2.02E-04 YBR154C YDL051W YDR045C YHR143W-A YJL011C YKL144C

YNL113W YNL151C YNR003C YPR110C YPR187W 11 38 12.04.01 Iniciación de la

traducción 3.33E-04 YBR079C YDR091C YDR211W YGR054W YGR162W YKR026C

YLR192C YLR291C YMR309C YOR260W YOR361C 11 40 01.05.13.03 Tetrahidrofolato-

dependente de la transferencia

de grupo C-1 3.59E-04 YBR084W YDR408C YGR204W YKR080W YLR058C YMR120C 6 13

01.01.09.01.02 Degradación de

glicina 6.54E-04 YAL044C YDR019C YLR058C YMR189W 4 6

01.01 Metabolismo d

aminoácidos 1.07E-03 YAL021C YAL044C YBR084W YCL030C YCL064C YCR053W

YDL080C YDL219W YDR019C YDR111C YDR234W YDR321W 35 243

(30)

YER055C YGL148W YGR204W YGR208W YHR025W YKL029C YKL106W YKL181W YLR017W YLR058C YLR146C YLR172C YLR180W YLR438W YML096W YMR189W YNL247W YNL316C

YNR050C YOR184W YPL111W YPR060C YPR069C 12.10 Aminoacil-tRNA-

sintetasas 1.13E-03 YBL076C YDR023W YFL022C YGR094W YGR264C YLR060W

YNL247W YOL097C YOR168W YPL160W 10 39

cisteína-grupos aromáticos 2.45E-03 YAL044C YCL030C YCL064C YDR019C YER055C YGL148W YGR208W YHR025W YKL181W YLR058C YMR189W YNL247W

YNL316C YOR184W YPR060C 15 80

12.04 Traducción 2.48E-03 YBR079C YDL219W YDR091C YDR172W YDR211W YDR252W YGR054W YGR162W YKL081W YKR026C YLR192C YLR291C

YMR309C YOR260W YOR276W YOR361C 16 88

glicina 2.66E-03 YAL044C YDR019C YLR058C YMR189W 4 8

compuestos primarios del C 2.66E-03 YAL044C YDR019C YLR058C YMR189W 4 8

01.03.04.03 Anbolismo de

pirimidinas y nucleótidos 4.41E-03 YBL039C YEL021W YHR128W YKL181W YLR420W 5 14 11.04.02 Procesamiento de

tRNA 4.97E-03 YAL033W YAR008W YDL051W YDR395W YJR042W YKL205W

YKR079C YMR047C YMR235C YOL115W 10 47

compuestos primarios del C 5.24E-03 YAL044C YDR019C YMR189W 3 5

serina 6.16E-03 YCL064C YGR208W YHR025W YLR058C YOR184W 5 15

16.03.01 Unión de DNA 7.02E-03

YBR154C YDR045C YDR489W YGR140W YHR143W-A YJL011C YJL148W YJR063W YKL144C YLR103C YLR233C YLR453C YNL113W YNL151C YNL248C YNR003C YOL115W YOR340C

YOR341W YPL075W YPR010C YPR110C YPR187W

23 159

32.05.01.03 Resistencia a

agentes químicos 8.83E-03 YGL016W YLR397C YMR058W YNL264C YOR129C YOR153W

YPR198W 7 29

10.01.03 Reconocimiento del ORI y formación del complejo de

acrtivación 1.55E-02 YBL035C YBR060C YLL004W YLR002C YLR103C YNL261W 6 25

01.01.09.02.01 Biosíntesis de

serina 1.61E-02 YGR208W YLR058C YOR184W 3 7

(31)

pirimidinas y nucleótidos 1.73E-02 YBL039C YDL103C YEL021W YEL042W YHR128W YKL181W

YKL216W YLR420W YNL292W 9 48

32.05.01 Resistencia proteica 1.80E-02 YGL016W YLR397C YMR058W YNL264C YOR129C YOR153W

YPR198W 7 33

vitaminas, grupos prostéticos y

cofactores 1.91E-02

YAL044C YBR084W YBR092C YCR020C YCR053W YDL080C YDR019C YDR044W YDR541C YGL148W YGR204W YHL018W

YHR063C YKR080W YLR058C YLR146C YLR285W YMR189W YMR243C YOR143C YOR184W YPR069C

22 164

01.01.03.05.02 Degradación de

arginina 2.01E-02 YLR438W YPL111W 2 3

01.01.05.01.01 Biosíntesis de

poliaminas 2.01E-02 YLR146C YPR069C 2 3

01.01.06.04.01 Biosíntesis de

treonina 2.01E-02 YCR053W YHR025W 2 3

01 METABOLISMO 2.36E-02 YAL021C YAL044C YAR015W YBL039C YBR023C YBR042C YBR084W YBR092C YCL024W YCL030C YCL064C YCR020C YCR034W YCR048W YCR053W YDL040C YDL080C YDL093W YDL103C YDL219W YDR019C YDR020C YDR044W YDR091C YDR111C YDR172W YDR234W YDR245W YDR321W YDR384C

YDR408C YDR454C YDR541C YEL021W YEL042W YEL047C YER055C YER070W YGL022W YGL148W YGL225W YGL234W YGR061C YGR081C YGR123C YGR204W YGR208W YHL018W YHR013C YHR025W YHR063C YHR128W YHR133C YHR204W YIL009W YIR026C YJL091C YJL183W YJL187C YJL209W YJL212C

YJR132W YJR143C YKL008C YKL029C YKL104C YKL106W YKL127W YKL161C YKL181W YKL216W YKR080W YKR103W

YLL012W YLL031C YLL034C YLR017W YLR020C YLR032W YLR058C YLR088W YLR113W YLR131C YLR146C YLR172C YLR180W YLR188W YLR228C YLR242C YLR285W YLR359W YLR397C YLR420W YLR432W YLR438W YML016C YML022W YML056C YML086C YML096W YMR001C YMR006C YMR058W YMR080C YMR120C YMR189W YMR215W YMR217W YMR243C YMR246W YMR277W YMR296C YMR300C YNL038W YNL207W YNL220W YNL222W YNL247W YNL261W YNL264C YNL280C

YNL292W YNL316C YNR050C YOL002C YOL021C YOL059W YOL080C YOL090W YOL101C YOL115W YOL149W YOR067C YOR081C YOR095C YOR101W YOR128C YOR143C YOR184W

147 1514

(32)

YOR377W YPL075W YPL111W YPL145C YPL227C YPR048W YPR060C YPR069C

32.05 Virulencia y defensa 2.45E-02 YGL016W YLR397C YMR058W YNL264C YOR129C YOR153W

YPR198W 7 35

20.01.13 Transporte de lípidos y

ácidos grasos 2.86E-02 YDR093W YJL145W YLR242C YLR380W YMR079W YMR246W

YNL264C YOR153W 8 44

creatina y poliaminas 3.22E-02 YLR146C YLR438W YPL111W YPR069C 4 15

20.03.01 Transporte a través de

canales y poros 3.22E-02 YIL114C YJL039C YNL291C YPL125W 4 15

treonina 3.41E-02 YCL064C YCR053W YHR025W 3 9

aminas 3.80E-02 YLR146C YPR069C 2 4

20.03.01.05 Proteínas

formadoras de poros nucleares 3.80E-02 YJL039C YPL125W 2 4

10.01.03 Síntesis de DNA y

replicación 4.08E-02 YAL033W YAL040C YBL035C YBR060C YDR206W YDR489W YER070W YGR109C YJR043C YLL004W YLR002C YLR103C

YLR233C YLR318W YMR001C YMR241W YNL261W YOL115W 18 138 20.01.27 Transporte de

drogas/toxinas 4.20E-02 YDR119W YHR032W YHR048W YNR055C YOL158C YOR153W

YPR198W 7 39

E

(33)

CATEGORÍA FUNCIONAL MIPS p-VALOR GENES CLUSTER GENOMA

11.04.01 Procesamiento de

rRNA 3.19E-20

YAL033W YBR142W YBR247C YCR057C YDL060W YDL148C YDL166C YDL208W YDR083W YDR087C YDR280W YDR324C YDR398W YDR449C YER082C YER127W YER146W YGR090W YGR095C YGR128C YGR158C YGR159C YHR062C YHR065C YHR072W-A YHR085W YHR148W YHR196W YHR197W YJL010C

YJL069C YJR022W YKL009W YKL099C YKL172W YKR024C YKR060W YKR081C YLL008W YLL011W YLL035W YLR002C YLR022C YLR068W YLR129W YLR186W YLR192C YLR222C YLR223C YLR276C YLR409C YLR435W YMR049C YMR235C YNL075W YNL207W YNL222W YNR038W YNR054C YOL021C YOL080C YOL115W YOR001W YOR004W YOR145C YOR294W YPL043W YPL126W YPL146C YPL211W YPL266W YPR137W

72 205

11 TRANSCRIPCIÓN 8.61E-14 YAL021C YAL033W YAL043C YBL024W YBL074C YBR049C YBR055C YBR061C YBR084W YBR121C YBR130C YBR142W YBR154C YBR247C YCR020C YCR052W YCR057C YCR065W YCR084C YCR087C-A YDL036C YDL060W YDL112W YDL148C

YDL150W YDL160C YDL166C YDL201W YDL208W YDL219W YDR083W YDR087C YDR120C YDR138W YDR165W YDR252W

YDR257C YDR280W YDR324C YDR395W YDR398W YDR449C YDR496C YDR501W YEL055C YER082C YER127W YER130C YER146W YER171W YER172C YFR037C YGL014W YGL092W YGL112C YGL207W YGL232W YGR090W YGR095C YGR097W

YGR128C YGR158C YGR159C YGR200C YHR062C YHR065C YHR072W-A YHR084W YHR085W YHR143W-A YHR148W YHR167W YHR170W YHR196W YHR197W YIL091C YIL126W YIL128W YIR023W YJL010C YJL069C YJL125C YJL148W YJL176C

YJR022W YJR032W YJR042W YJR063W YJR147W YKL009W YKL072W YKL078W YKL099C YKL125W YKL144C YKL172W YKL205W YKR024C YKR060W YKR079C YKR081C YKR092C YLL004W YLL008W YLL011W YLL035W YLL054C YLR002C YLR014C YLR022C YLR068W YLR115W YLR129W YLR141W

YLR147C YLR186W YLR192C YLR222C YLR223C YLR226W YLR228C YLR256W YLR276C YLR277C YLR316C YLR321C YLR384C YLR398C YLR401C YLR409C YLR418C YLR435W

195 1077

(34)

YLR442C YLR451W YML010W YML027W YML043C YML080W YMR047C YMR049C YMR080C YMR125W YMR131C YMR235C YMR277W YNL062C YNL075W YNL113W YNL175C YNL207W YNL222W YNL248C YNL261W YNR003C YNR038W YNR046W YNR054C YNR063W YOL021C YOL055C YOL080C YOL093W YOL115W YOL124C YOL149W YOR001W YOR004W YOR038C YOR046C YOR083W YOR145C YOR151C YOR204W YOR207C YOR224C YOR243C YOR294W YOR334W YOR340C YOR341W YPL037C YPL043W YPL075W YPL126W YPL127C YPL128C YPL146C YPL190C YPL211W YPL212C YPL266W YPR010C

YPR070W YPR110C YPR137W

11.04 Procesamiento de RNA 3.66E-13

YAL021C YAL033W YAL043C YBL074C YBR055C YBR130C YBR142W YBR247C YCR057C YDL060W YDL148C YDL160C YDL166C YDL208W YDR083W YDR087C YDR280W YDR324C YDR395W YDR398W YDR449C YER082C YER127W YER146W YER172C YGL014W YGL092W YGR090W YGR095C YGR128C YGR158C YGR159C YHR062C YHR065C YHR072W-A YHR085W

YHR148W YHR196W YHR197W YIL091C YJL010C YJL069C YJR022W YJR042W YKL009W YKL078W YKL099C YKL172W YKL205W YKR024C YKR060W YKR079C YKR081C YLL008W YLL011W YLL035W YLR002C YLR022C YLR068W YLR115W YLR129W YLR147C YLR186W YLR192C YLR222C YLR223C YLR276C YLR277C YLR398C YLR409C YLR435W YMR047C YMR049C YMR080C YMR125W YMR235C YNL062C YNL075W

YNL207W YNL222W YNR038W YNR054C YOL021C YOL080C YOL115W YOL149W YOR001W YOR004W YOR046C YOR145C

YOR204W YOR294W YOR334W YPL043W YPL126W YPL146C YPL190C YPL211W YPL266W YPR137W

100 436

11.06 Modificación de RNA 3.49E-11

YBL024W YBR061C YBR084W YDL036C YDL112W YDL201W YDL208W YDL219W YDR120C YDR165W YER127W YGL232W

YHR072W-A YHR148W YJL125C YLL011W YLR316C YLR401C YML080W YNL062C YNL075W YNR046W YOL093W YOL124C

YOR243C YPL212C YPL266W YPR137W

28 64

16.03 Unión de ácidos

nucleicos 8.82E-11 YAL043C YBR130C YBR154C YBR247C YCR057C YDL148C YDL150W YDL208W YDR324C YDR398W YDR449C YDR489W YER007C-A YER082C YER127W YGL014W YGL232W YGR090W

YGR128C YGR159C YHR066W YHR072W-A YHR143W-A YHR148W YHR170W YHR196W YJL010C YJL069C YJL072C

79 341

(35)

YJL148W YJL194W YJR063W YKL099C YKL144C YKL205W YKR060W YKR081C YLL011W YLR103C YLR115W YLR129W

YLR141W YLR147C YLR186W YLR192C YLR222C YLR233C YLR277C YLR409C YLR448W YLR453C YML027W YMR094W YMR125W YMR168C YNL075W YNL113W YNL175C YNL197C YNL248C YNR003C YOL041C YOL115W YOL124C YOL149W YOR151C YOR207C YOR224C YOR340C YOR341W YPL043W

YPL075W YPL126W YPL127C YPL128C YPL190C YPR010C YPR110C YPR137W

16 PROTEÍNAS CON FUNCIÓN DE UNIÓN O REQUERIMIENTO DE COFACTORES (estructural o catalítico)

1.69E-10 YAL043C YAR033W YBR084W YBR130C YBR142W YBR154C YBR155W YBR208C YBR247C YCR057C YDL060W YDL092W YDL116W YDL148C YDL150W YDL160C YDL201W YDL208W YDL212W YDL226C YDL235C YDR011W YDR091C YDR138W YDR165W YDR212W YDR252W YDR292C YDR324C YDR398W YDR449C YDR489W YEL013W YER007C-A YER023W YER082C YER127W YER172C YFR002W YFR009W YFR013W YGL014W YGL092W YGL232W YGL234W YGR078C YGR090W YGR128C YGR159C YGR173W YGR285C YHR052W YHR065C YHR066W

YHR072W-A YHR084W YHR128W YHR143W-A YHR148W YHR167W YHR170W YHR196W YIL008W YIL026C YIL126W YIL138C YJL010C YJL014W YJL061W YJL069C YJL072C YJL085W

YJL148W YJL179W YJL194W YJL204C YJR032W YJR042W YJR063W YJR070C YKL099C YKL144C YKL205W YKR024C YKR060W YKR079C YKR081C YKR082W YKR092C YKR103W

YLL008W YLL011W YLL034C YLL048C YLR002C YLR008C YLR032W YLR095C YLR103C YLR115W YLR129W YLR141W

YLR147C YLR148W YLR166C YLR186W YLR188W YLR192C YLR200W YLR222C YLR233C YLR243W YLR274W YLR276C YLR277C YLR306W YLR313C YLR319C YLR321C YLR381W YLR396C YLR397C YLR409C YLR429W YLR442C YLR448W YLR453C YML027W YML086C YML094W YML103C YMR047C YMR080C YMR094W YMR125W YMR168C YMR192W YNL075W

YNL113W YNL153C YNL175C YNL197C YNL248C YNL261W YNR003C YNR038W YNR054C YOL041C YOL059W YOL090W YOL095C YOL115W YOL124C YOL149W YOR011W YOR143C YOR145C YOR151C YOR153W YOR207C YOR217W YOR224C YOR265W YOR340C YOR341W YPL037C YPL043W YPL075W YPL126W YPL127C YPL128C YPL146C YPL190C YPL210C

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