[PDF] Top 20 Competencias laborales del profesional en comercio internacional en las empresas modernas
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Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans
... Cryptococcus neoformans is a fungal human pathogen that causes meningitis in a predominantly immunocompromised population ...the central nervous system (CNS), cryptococcal cells ... See full document
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Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease
... ABSTRACT Cryptococcus spp. cause life-threatening fungal infection of the central nervous system (CNS), predominantly in pa- tients with a compromised immune ...Why Cryptococcus ... See full document
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Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood–brain barrier model for drug permeability studies
... in vitro , and in vivo BBB models for early prediction of brain perme- ability of compounds have been developed and estab- lished ...situ brain perfusion pro- vide high-quality data and some of the ... See full document
5
Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood–brain barrier model
... The human brain is protected by the existence of the blood–brain barrier (BBB), which consists of brain capil- lary endothelial cells linked with tight junctions ...the ... See full document
12
Impact of cigarette smoke extract and hyperglycemic conditions on blood–brain barrier endothelial cells
... in brain microenvironment are characteristically accom- panied by BBB dysfunction [20], thereby emphasizing the necessity of maintaining a proper barrier function and integrity to conserve the brain ... See full document
26
CNS endothelium expression of ADAM 17 and its role in multiple sclerosis pathogenesis
... on brain capillaries in chronic silent MS lesions have suggested that BBB abnormalities persist, even in the absence of active inflammation (Kwon and Prineas, 1994; Claudio et ...Other studies using ... See full document
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Breast cancer brain metastases: biology and new clinical perspectives
... cellular barrier selectively regulates the exchange between blood and brain compartments by preventing the paracellular diffusion of hydrophilic compounds, thereby mediating the transport of ... See full document
9
Comparison Between Folic Acid and gH625 Peptide Based Functionalization of Fe3O4 Magnetic Nanoparticles for Enhanced Cell Internalization
... from human brain, which are the main components of the BBB and simulate an in vitro model of the ...in vitro BBB, leading to significant higher cell uptake in HBMEC after 24 h ... See full document
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Targeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation?
... B cell responses, especially in the context of HIV infection, GPIIb-IIIa is a platelet-specific integrin, sugges- ting that off-target effects would be ... See full document
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Expression and localization of claudins-3 and -12 in transformed human brain endothelium
... the hCMEC/D3 culture ...the barrier properties by up-regulating expres- sion or localization of ...rested hCMEC/D3 cells were cultured with or without 1 nM simvastatin for 12 h (Figure ... See full document
6
Region-specific blood–brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease
... in vitro models and an in vivo animal model of AD as well as patient ...In vitro and in silico studies indicated that amisulpride was not a substrate for ABC transporters including ... See full document
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Microvascular endothelial cells-derived microvesicles imply in ischemic stroke by modulating astrocyte and blood brain barrier function and cerebral blood flow
... total cell proteins (40 μg) extracted from each group were separated by 12 % SDS-PAGE on tris-glycine gels (Invitrogen) and transferred to polyvinylidene difluoride membranes (Millipore Corp, Bedford, ... See full document
22
MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium
... Increased human brain endothelial miR-126 expression remarkably decreased shear resistant T cell and monocyte adhesion by almost 50% to both unstimulated ...cytokine-treated human ... See full document
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Focused Ultrasound Immunotherapy for Central Nervous System Pathologies: Challenges and Opportunities
... immune system responds to antigens in the brain are still not fully understood; this provides an additional challenge for tuning therapeutically relevant immune responses in the brain, and highlights ... See full document
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Blood brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease
... cross human brain micro- vascular endothelial cells (BMECs), a human blood-brain barrier (BBB) model system, at much greater effi- ciency than do ...of ... See full document
6
Current approaches to enhance CNS delivery of drugs across the brain barriers
... the blood–cerebrospinal fluid (CSF) barrier (BCSFB), not only play a critical role in protecting the CNS against toxic and infectious agents while maintaining the ionic and volumetric environments, but also ... See full document
5
PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies
... across brain endothelium and examine the mechanism of nanoparticle ...mouse model of Alzheimer’s disease ...in vitro, using a human brain endothelial cell line, ... See full document
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Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line
... of endothelial dysfunction, increased vascular perme- ability, and altered gene expression, thus leading to poten- tial neuronal ...and human studies ...perimental studies has been reported in ... See full document
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Application of dental nanomaterials: potential toxicity to the central nervous system
... Nanomaterials have made major contributions to modern dentistry in various areas, including composite resin and bonding systems, coating materials for dental implants, and dental restorations. The wide applications of ... See full document
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Comparison of apoptosis in human primary pulmonary endothelial cells and a brain microvascular endothelial cell line co cultured with Plasmodium falciparum field isolates
... and hCMEC cell line was incubated with 3D7 stain as positive control and uninfected RBC as negative ...and hCMEC/D3 to RBC- activated HLEC and hCMEC/D3 and mean OD of 3D7- ... See full document
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