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Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD
... All subjects gave written informed consent prior to participa- tion. We included those who were older than 45 years with more than a 15 pack-year history of smoking. Subjects with a history suggestive of asthma, ... See full document
8
Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma
... the COPD with asthma group included asthmatic patients with airway remodeling in this study, because it is sometimes difficult to clinically differentiate such patients from COPD patients who ... See full document
60
Airway remodelling in smokers with or without chronic obstructive pulmonary disease (COPD) and the effects of inhaled corticosteroids on remodelling in COPD
... date. All 4 were stored at ...and Vascular Endothelial Growth Factor (VEGF) (Fitzgerald, Concord ...from all four biopsies were controlled by our laboratory manager and one of them was selected for ... See full document
212
Eosinophilic airway inflammation in COPD
... eosinophilic airway inflammation in COPD is unclear, although it is widely assumed that it indicates an asthmatic component to the fixed airways obstruction (Barnes ...with COPD rigorously exclude ... See full document
6
Airway remodeling in asthma
... allow remodeling paradigms to begin to be ...prominent airway fibrosis, with prominent myocyte and myofibroblast ...IL-11, airway obstruction and AHR are also ...recapitulate all of the ... See full document
5
Severe exacerbation and pneumonia in COPD patients treated with fixed combinations of inhaled corticosteroid and long-acting beta2 agonist
... The Taiwan National Health Insurance Research Database (NHIRD) consists of standard computerized claims docu- ments submitted by medical institutions seeking reimburse- ment through the National Health Insurance (NHI) ... See full document
13
<p>Association Between Adherence to Maintenance Medication in Patients with COPD and Acute Exacerbation Occurrence and Cost in China: A Retrospective Cohort Database Study</p>
... in COPD and include the overuse of ...with COPD compared with that in clinical ...in COPD in a real-world setting in ...of COPD (AECOPD) and associated cost among patients with COPD in ... See full document
9
Pulmonary vascular effects of pulsed inhaled nitric oxide in COPD patients with pulmonary hypertension
... The objective of this exploratory study was to assess the effect of pulsed iNO on vascular geometry in subjects with COPD-related PH who are on LTOT. The primary end point was the change in lobar blood ... See full document
9
The association of neuron-derived orphan receptor 1 with pulmonary vascular remodeling in COPD patients
... or lung carcinoma from January 2012 to December 2013 in our hospital. Lung tissue samples were obtained from normal appearing areas of the pulmonary parenchyma as far as pos- sible from the tumor (at least 2 cm). ... See full document
10
Original Article Mesenchymal stem cells suppress lung inflammation and airway remodeling in chronic asthma rat model via PI3K/Akt signaling pathway
... way remodeling could be through a PI3K/Akt ...accumulation, airway remodeling and also ...treating airway remodeling and inflammation in asthma through induction of the production of ... See full document
30
Inhaled corticosteroid use in patients with chronic obstructive pulmonary disease and the risk of pneumonia: a retrospective claims data analysis
... The Cox proportional hazards model was used to compare the risk of pneumonia among low-dose, medium-dose, and high-dose ICS use compared with no ICS use. The ICS use was modeled as a time-dependent variable, and a ... See full document
11
<p>Prevalence of Frailty and Evaluation of Associated Variables Among COPD Patients</p>
... adjusted including the variables separately. The ordinal regres- sion models were evaluated and validated to con fi rm the proportional odds assumption using a likelihood-ratio test and a Brant test. As MRC and CAT were ... See full document
8
Chronic allograft rejection: A significant hurdle to transplant success
... failure. All the existing immunosuppressive regimens are targeting acute rejection, and at present there is no available therapy for prevention of chronic ... See full document
28
<p>How Do Innate Immune Cells Contribute to Airway Remodeling in COPD Progression?</p>
... for COPD mainly consists of broncho- dilatation, anti-in fl ammation, and ...reverse airway remodeling and the sub- sequent irreversible obstructive air fl ow, modulation of the immune-imbalance in the ... See full document
11
Alzain
... chronic airway inflammation, remodeling of the airway wall, and airway hyper-responsiveness to leading to spasms in response to stimuli inducing a reversible airflow ...understand all ... See full document
14
Extrafine inhaled corticosteroid therapy in the control of asthma
... Asthma control Better asthma control total score, daytime symptom score, and rescue medication use score; lower mean daily ICS dose while treated with HFA-BDP/formoterol. Abbreviations: CFC, chlorofluorocarbon; BDP, ... See full document
8
Nasal high flow, but not supplemental O<sub>2</sub>, reduces peripheral vascular sympathetic activity during sleep in COPD patients
... moderate COPD, which clearly limits any conclusion to be drawn on the overall clinical significance of our ...in COPD patients stage III and ...doing some multivariate regression ... See full document
72
Morphological changes in small pulmonary vessels are associated with severe acute exacerbation in chronic obstructive pulmonary disease
... Using the optimal cutoff value of %CSA , 5 , significantly higher incidence of severe AE-COPD was observed among patients with the lower %CSA , 5 than those with the higher %CSA , 5 (Gray’s test, P= 0.011; Figure ... See full document
20
Quadrupling or quintupling inhaled corticosteroid doses to prevent asthma exacerbations: The jury's still out
... ABSTRACTED FROM: Jackson, D.J., Bacharier, L.B., Mauger, D.T., Boehmer, S., Beigelman, A., Chmiel, J.F., Fitzpatrick, A.M., Gaffin, J.M., Morgan, W.J., Peters, S.P. and Phipatanakul, W., 2018. Quintupling inhaled ... See full document
37
Scientific rationale for the possible inhaled corticosteroid intraclass difference in the risk of pneumonia in COPD
... the airway epithelial lining fluid in the form of particles for many hours after inhalation, while budesonide is dissolved within ...in airway epithelial lining fluid, will be rec- ognized by ... See full document
12
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