[PDF] Top 20 A lei Maria da Penha sob uma perspectiva do direito feminista
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Effect of glutamine or glucose deprivation on the expression of cyclin and cyclin-dependent kinase genes in glioma cell line U87 and its subline with suppressed activity of signaling enzyme of endoplasmic reticulum–nuclei-1
... показано, що ішемія індукує комплекс складних внутрішньоклітинних сигнальних подій, відомих як реакція на неправильне згортання протеїнів, яка опосередковується сенсорним ензимом ендоплазматичний рети- ... See full document
9
Expression of casein kinase genes in glioma cell line U87: Effect of hypoxia and glucose or glutamine deprivation
... The endoplasmic reticulum-nuclei-1 (ERN1) se- nsing and signaling enzyme mediates a set of complex intracellular signaling events known as the unfolded protein ...the ... See full document
113
Expression of ubiquitin specific peptidase and ATG7 genes in U87 glioma cells upon glutamine deprivation
... nutrient deprivation and acidosis, which promote neovascularisation, cell survival and pro- liferation ...[37-40]. Glucose and glutamine are sub- strates for glycolysis and glutaminolysis, ... See full document
6
Inhibition of IRE1 modifies effect of glucose deprivation on the expression of TNFα-related genes in U87 glioma cells
... and kinase activities of IRE1 signaling enzyme in U87 glioma cells, causes a strong (more than 8-fold) increase in the levels of TNFRSF21 mRNA, which is known as death re - ceptor 6, ... See full document
44
Effect of hypoxia on the expression of CCN2, PLAU, PLAUR, SLURP1, PLAT and ITGB1 genes in ERN1 knockdown U87 glioma cells
... The glioma cell line U87 was obtained from ATCC (USA) and grown in high glucose ...with glutamine (2 mM), 10% fetal bovine serum (EquitechBio, ...this glioma cell ... See full document
7
Effect of hypoxia and glutamine or glucose deprivation on the expression of retinoblastoma and retinoblastoma related genes in ERN1 knockdown glioma U87 cell line
... the signaling activity of the enzyme endoplasmic reticulum-nuclei-1 leads to a significant induction of the expression of genes that en- code tumor ... See full document
112
Effect of hypoxia on the expression of genes that encode some IGFBP and CCN proteins in U87 glioma cells depends on IRE1 signaling
... in glioma cells by inhibi- tion of IRE1 signaling enzyme, which supports the IRE1-mediated mechanisms of the expression of both these ...the expression of these multifunctional proteins ... See full document
8
Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis
... the kinase dead KE mutant of cyclin D1 led to aneuploidy, abnormalities in mitotic spindle formation, autosome amplification, and chromosomal instability (CIN) by gene expression ...transgenic ... See full document
193
Effect of hypoxia on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells
... functional activity of mitochondria is controlled through numerous nuclear-encoded mi- tochondrial proteins, and most of these factors and enzymes are responsible for metabolic reprogram- ming of mitochondria in ... See full document
45
MAGI3 negatively regulates Wnt/ -catenin signaling and suppresses malignant phenotypes of glioma cells
... tyrosine kinase signaling ...Wnt/β-catenin signaling has been implicated in a variety of human cancers including ...as cell proliferation, survival, differentiation, migration and polarity ... See full document
61
Effect of Metal Ions and Enzyme Inhibitor on the Activity of Cellulase Enzyme of Aspergillus flavus
... A column (18x1.5 cm), packed with Q-Sepharose fast flow was set up and washed with 150 ml of 0.2 M phosphate buffer (pH 6.8) to equilibrate the resin to the buffer pH. Then, 20 ml of the enzyme concentrate was ... See full document
12
Changes in the expression of cyclin dependent kinase inhibitors during differentiation of immortalized fibroblasts into adipocytes
... Cells were washed in PBS and incubated in trypsin-EDTA. Then, they were resuspended in RIPA buffer and further dissociated by passing various times through G21 needle followed by incubation on ice for 45 min and ... See full document
17
Penta O galloyl β D glucose induces G1arrest and DNA replicative S phase arrest independently of P21 cyclin dependent kinase inhibitor 1A, P27 cyclin dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth
... The animal use protocol was approved by the Kyung Hee University Institutional Animal Care and Use Com- mittee and carried out at the Cancer Preventive Mate- rial Development Research Center, College of Oriental ... See full document
12
Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancer cells
... Notes: lncaP and DU145 cells were transfected with the indicated dsrnas at 50 nM for 72 hours or mock transfected for 72 hours. (A) schematic representation of the p53 promoter and dsP53-285 target site. The sequences at ... See full document
18
Inhibition of basal and mitogen stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum
... in cell cycle ...elevated cyclin D1 levels correlate with decreased survival in human pancreatic ...a cyclin D1 antisense cDNA construct in PANC-1 human pancreatic cancer ...cells. ... See full document
7
Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
... B cell malignancy and autoimmune diseases Lymphoma, including B and T-cell lymphoma, is malig- nancy of lymphatic cells, which affects more than a mil- lion people ...B cell lymphomagenesis are also ... See full document
7
Identification of core genes in ovarian cancer by an integrative meta-analysis
... protein expression of these hub genes might be instructive to the further ...protein expression data of hub genes is acquired from the Human Protein Atlas for ...hub genes (CDK1, TOP2A, ... See full document
48
Expression of tumor growth related genes in IRE1 knockdown U87 glioma cells: effect of hypoxia
... cancer 1, early onset (BRCA1), also known as RING finger protein 53 (RNF53) and protein phosphatase 1, regulatory subunit 53, was performed using the forward primer (5′-TGAAGAAAGAGGAACGGGCT-3′) and re- ... See full document
8
Downregulation of cyclin dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
... cdk2 activity and repressed transcription from the 279/1100 cyclin A promoter region, which contains an E2F-binding site required for cell cycle–regulated cyclin A gene expression ... See full document
72
Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
... Cancer is considered to be a disease of the cell cycle, as cancer cells lose the stringent controls normally present during cell cycle progression. This is often the result of mutations via DNA damage; such ... See full document
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