[PDF] Top 20 Wnt signaling in the nervous system and in Alzheimer's disease
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Wnt signaling in the nervous system and in Alzheimer's disease
... that Wnt ligands exert modulatory effects on glutamatergic neuro- ...observed in hippocampal slices that blockade of Wnt signaling impairs long-term potentiation (LTP), whereas ac- tivation of ... See full document
11
Signaling pathway cross talk in Alzheimer's disease
... tion in AD can be summarized by at least five general statements: (i) reduced energy metabolism due to alter- ations in the key enzymes involved in oxidative phosphor- ylation, are associated ... See full document
12
Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1 Delta E9 mouse model of Alzheimer's disease
... cortex and hippocampus was also significantly reduced in lithium- and rosiglitazone-treated mice in comparison with that in control transgenic mice, and showed intensities ... See full document
15
Wnt signaling in the regulation of adult hippocampal neurogenesis
... with the GSK-3 β inhibitor lithium induces the prolifer- ation of AHPs (Wexler et ...2008). In vivo treatment with lithium was also shown to stimulate proliferation and neuronal fate speci- ... See full document
11
Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20 APP transgenic and wild type mice
... increase the levels of the Wnt7a/b and Wnt5a ligands in the rat hippocampus (Tabatadze et ...2012), and canonical Wnt signaling is necessary for hippocampal memory ... See full document
23
Synaptic Wnt/GSK3β Signaling Hub in Autism
... abundant in the brain. Two homologous isoforms, GSK3𝛼 and GSK3𝛽, have been described in mammals and are involved in multiple cellular processes including glycogen metabolism, ... See full document
11
Canonical Wnt signaling protects hippocampal neurons from A beta oligomers: role of non canonical Wnt 5a/Ca2+ in mitochondrial dynamics
... Alzheimer’s disease (AD) is the most common type of age-related dementia. The disease is characterized by a progressive loss of cognitive abilities, severe neurodegeneration, synaptic loss ... See full document
12
Involvement of WNT signaling pathway in the adult hippocampal synapses :role in neuroprotection
... Infusion system preparation. Animals received bilateral chronic infusion into the CA1 hippocampal region with: (a) WASP-1 (Wnt-activating small molecule), a potentiator of the canonical ... See full document
137
Emerging Roles of Extracellular Vesicles in the Nervous System
... roles in physiological processes, such as neuronal development, repair, and synaptic function, EVs/exosomes also contribute to the development of disease ...Parkinson’s disease, ... See full document
8
Wnt signaling in skeletal muscle dynamics: Myogenesis, neuromuscular synapse and fibrosis
... Abstract The signaling pathways activated by Wnt ligands are related to a wide range of critical cell functions, such as cell division, migration, and ...on the role of Wnt ... See full document
16
Brain insulin signaling in Alzheimer's disease
... learning and memory in animal models ...is the case of one study using NIRKO mice (mice with neuron-specific disruption of the IR gene) which showed no spatial memory alterations or even some ... See full document
48
Melatonin and mitochondrial dysfunction in the central nervous system
... including Alzheimer´s disease (AD), Parkinson´s disease (PD) and Huntington’s disease ...stress and increased apoptosis in different areas of the ... See full document
28
In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model
... of Wnt/-catenin signaling can modulate amygdala-dependent fear memory for- mation (Maguschak and Ressler, 2008, ...of Wnt signaling could also participate in ... See full document
12
Wnt Signaling: Role in Alzheimer Disease and Schizophrenia
... of Wnt signaling cannot only be attributed to a loss of function. In fact, the reduction in the Wnt signal- ing can be due to a gain of function of inhibitors of ... See full document
20
The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease
... found in neuronal cell bodies and neurites [42], where it is found co-localized with the neurofibrillary changes observed in AD ...brains. The activation of the enzyme GSK-3β, ... See full document
13
Wnts in adult brain: from synaptic plasticity to cognitive deficiencies
... During the last decades, increasing data has suggested that the progression of a neurological disease is the result of severe neu- roanatomical ...changes in the synaptic ... See full document
16
Emerging roles of Wnts in the adult nervous system
... made in deciphering the roles of Wnt signalling during neural development, little is known about the roles of Wnts in the adult nervous ...that Wnt pathways modu- ... See full document
10
The endocannabinoid system in chronic liver disease
... Despite the public concern about the controversial use and abuse of marijuana, the scientific community has fo- cused on the therapeutic potentials of cannabinoid com- pounds and ... See full document
8
Efecto de HOTAIR sobre TET1 y la vía WNT en la línea celular HeLa.
... La disminución de TET1 es un evento que ocurre en múltiples enfermedades, entre ellas el cáncer (Tan and Shi, 2012). En cáncer, se han reportado niveles reducidos de esta proteína. Además, la re-expresión de TET1 ... See full document
16
Functional Role of Connexins and Pannexins in the Interaction Between Vascular and Nervous System
... at the plasma membrane, of two hemichannels ...cell. In turn, hemi- channels are made up by the arrangement of six connexin (Cx) proteins around a ...described in mammals and each ... See full document
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